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Cytoprotective Silica Coating of Individual Mammalian Cells through Bioinspired Silicification
- Source :
- Angewandte Chemie. 126:8194-8197
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- The cytoprotective coating of physicochemically labile mammalian cells with a durable material has potential applications in cell-based sensors, cell therapy, and regenerative medicine, as well as providing a platform for fundamental single-cell studies in cell biology. In this work, HeLa cells in suspension were individually coated with silica in a cytocompatible fashion through bioinspired silicification. The silica coating greatly enhanced the resistance of the HeLa cells to enzymatic attack by trypsin and the toxic compound poly(allylamine hydrochloride), while suppressing cell division in a controlled fashion. This bioinspired cytocompatible strategy for single-cell coating was also applied to NIH 3T3 fibroblasts and Jurkat cells.
- Subjects :
- Cell division
biology
Chemistry
General Chemistry
General Medicine
engineering.material
Gene delivery
biology.organism_classification
Silicon Dioxide
Jurkat cells
Catalysis
Allylamine
HeLa
Cell therapy
chemistry.chemical_compound
Coating
Biochemistry
Cytoprotection
Biophysics
engineering
Animals
Humans
Cytotoxicity
HeLa Cells
Subjects
Details
- ISSN :
- 00448249
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie
- Accession number :
- edsair.doi.dedup.....36271522ff0123af2e79d4e27fc5aebc