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Bridging large bone defects with a xenograft composited with autologous bone marrow
Bridging large bone defects with a xenograft composited with autologous bone marrow
- Source :
- International Orthopaedics. 6:79-85
- Publication Year :
- 1982
- Publisher :
- Springer Science and Business Media LLC, 1982.
-
Abstract
- We have investigated the role of defatted, decalcified xenogenic bone implants composited by impregnation with fresh autologous marrow in bridging large cortical defects. Diaphyseal cortical implants were obtained from orthopaedic operations on humans and from guinea pigs and prepared by treatment with acetone, 0.6 M HCl and ethanol. The composited graft was used to bridge a 3 cm defect in the diaphysis of the ulna of rabbits. Periodic investigations were made clinically, radiographically and histologically and by tetracycline, fluorescence studies up to 20 weeks. Abundant new bone formation was observed in 85.7% of composited human xeno-autografts and in 83.3% of composited guinea pig xeno-autografts. New bone formation was seen in 13.3% of noncomposited xeno-implants. No appreciable antigenicity was observed either clinically or histologically in the grafts. The high degree of success obtained justifies further studies on implants composited by fresh autologous marrow and offers hope for the enhancement of new bone formation clinically, particularly in reconstructive operations for significant skeletal defects. We feel that the osteo-inductive potential of autologous marrow was responsible for the healing of the defects aided by the better internal milieu provided by defatted decalcified xeno implant.
- Subjects :
- Graft Rejection
Pathology
medicine.medical_specialty
Autologous marrow
Guinea Pigs
Transplantation, Heterologous
Transplantation, Autologous
Bone and Bones
Osteogenesis
medicine
Animals
Humans
Orthopedics and Sports Medicine
Bone formation
Bone Marrow Transplantation
Bone Transplantation
business.industry
Bone implant
Graft Survival
Ulna
Autologous bone
Diaphysis
medicine.anatomical_structure
Surgery
Rabbits
Implant
Bone marrow
Bone Diseases
business
Subjects
Details
- ISSN :
- 14325195 and 03412695
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- International Orthopaedics
- Accession number :
- edsair.doi.dedup.....36424e8a679e658957198b68a6b66246
- Full Text :
- https://doi.org/10.1007/bf00268649