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Bridging large bone defects with a xenograft composited with autologous bone marrow

Bridging large bone defects with a xenograft composited with autologous bone marrow

Authors :
D. Gupta
Surbhi Khanna
S. M. Tuli
Source :
International Orthopaedics. 6:79-85
Publication Year :
1982
Publisher :
Springer Science and Business Media LLC, 1982.

Abstract

We have investigated the role of defatted, decalcified xenogenic bone implants composited by impregnation with fresh autologous marrow in bridging large cortical defects. Diaphyseal cortical implants were obtained from orthopaedic operations on humans and from guinea pigs and prepared by treatment with acetone, 0.6 M HCl and ethanol. The composited graft was used to bridge a 3 cm defect in the diaphysis of the ulna of rabbits. Periodic investigations were made clinically, radiographically and histologically and by tetracycline, fluorescence studies up to 20 weeks. Abundant new bone formation was observed in 85.7% of composited human xeno-autografts and in 83.3% of composited guinea pig xeno-autografts. New bone formation was seen in 13.3% of noncomposited xeno-implants. No appreciable antigenicity was observed either clinically or histologically in the grafts. The high degree of success obtained justifies further studies on implants composited by fresh autologous marrow and offers hope for the enhancement of new bone formation clinically, particularly in reconstructive operations for significant skeletal defects. We feel that the osteo-inductive potential of autologous marrow was responsible for the healing of the defects aided by the better internal milieu provided by defatted decalcified xeno implant.

Details

ISSN :
14325195 and 03412695
Volume :
6
Database :
OpenAIRE
Journal :
International Orthopaedics
Accession number :
edsair.doi.dedup.....36424e8a679e658957198b68a6b66246
Full Text :
https://doi.org/10.1007/bf00268649