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The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment
- Source :
- Peter, Jessica; Mayer, Isabella; Kammer, Thomas; Minkova, Lora; Lahr, Jacob; Klöppel, Stefan; Grothe, Michel J.; Orth, Michael (2021). The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment. Scientific Reports, 11(1), p. 16080. Nature Publishing Group 10.1038/s41598-021-95573-8
- Publication Year :
- 2021
-
Abstract
- We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure of central cholinergic signal transmission. Healthy volunteers (n = 36) and patients with mild cognitive impairment (MCI, n = 20) underwent median nerve SAI and 3T structural MRI to determine the volume of the basal forebrain and the thalamus. Patients with MCI had smaller basal forebrain (p p 10% SAI) had more basal forebrain volume than non-responders (p = 0.004) or patients with MCI (p r = 0.33, p
- Subjects :
- Male
Cholinergic Agents
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging [Medical Subject Headings]
Neuropsychological Tests
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Thalamus
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Cholinergic Agents [Medical Subject Headings]
Phenomena and Processes::Physiological Phenomena::Electrophysiological Phenomena::Electrophysiological Processes::Neural Inhibition [Medical Subject Headings]
Voluntarios sanos
Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Thalamus [Medical Subject Headings]
Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]
Basal forebrain
Multidisciplinary
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
Medicine
Sensory processing
Female
Motor cortex
Adult
medicine.medical_specialty
Basal Forebrain
Science
Check Tags::Male [Medical Subject Headings]
Brain Structure and Function
Neural circuits
Article
Atrophy
Internal medicine
Persons::Persons::Volunteers::Healthy Volunteers [Medical Subject Headings]
medicine
Humans
Cognitive Dysfunction
Healthy volunteers
Persons::Persons::Age Groups::Adult [Medical Subject Headings]
Aged
business.industry
Prosencéfalo basal
Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]
Neural Inhibition
Disfunción Cognitiva
medicine.disease
Tálamo
Median nerve
Electrophysiology
Ageing
Endocrinology
Check Tags::Female [Medical Subject Headings]
Case-Control Studies
Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Neuropsychological Tests [Medical Subject Headings]
Cholinergic
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Peter, Jessica; Mayer, Isabella; Kammer, Thomas; Minkova, Lora; Lahr, Jacob; Klöppel, Stefan; Grothe, Michel J.; Orth, Michael (2021). The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment. Scientific Reports, 11(1), p. 16080. Nature Publishing Group 10.1038/s41598-021-95573-8 <http://dx.doi.org/10.1038/s41598-021-95573-8>, Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021), Digital.CSIC. Repositorio Institucional del CSIC, instname, Scientific Reports
- Accession number :
- edsair.doi.dedup.....36743737de97c7edbc398911136e4a27
- Full Text :
- https://doi.org/10.1038/s41598-021-95573-8