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Baseline Tumor Size as a Predictive and Prognostic Factor of Immune Checkpoint Inhibitor Therapy for Non-small Cell Lung Cancer
- Source :
- Anticancer research. 39(2)
- Publication Year :
- 2018
-
Abstract
- Background/aim Immune checkpoint inhibitors (ICI) are a novel medication for non-small cell lung cancer (NSCLC). Recent reports indicated that baseline tumor size (BTS) relates to the efficacy of ICI therapy for melanoma, but no study exists for NSCLC. This study aimed to evaluate the utility of BTS for ICI therapy. Patients and methods Data from 58 patients diagnosed with NSCLC who underwent ICI monotherapy, were retrospectively analyzed. Patients were divided into two groups according to BTS (below 101 mm, above 101 mm). The primary endpoint was progression-free survival (PFS) and the secondary endpoint was overall survival (OS). Results PFS of patients with a large BTS was significantly shorter than that of those with a small BTS (median; 2.07 [95% confidence interval [CI]=0.99-6.77] months versus 6.39 [95%CI=4.17-11.50] months) (p=0.044). OS of patients with large BTS was also significantly shorter (p Conclusion BTS is a predictive and prognostic negative factor of ICI therapy for NSCLC.
- Subjects :
- Oncology
Male
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Immune checkpoint inhibitors
Kaplan-Meier Estimate
Antibodies, Monoclonal, Humanized
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Antineoplastic Agents, Immunological
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Clinical endpoint
Biomarkers, Tumor
Humans
Progression-free survival
Lung cancer
Aged
Retrospective Studies
Tumor size
business.industry
Melanoma
Antibodies, Monoclonal
General Medicine
Middle Aged
medicine.disease
Prognosis
Confidence interval
Nivolumab
Treatment Outcome
030220 oncology & carcinogenesis
Female
Non small cell
business
Subjects
Details
- ISSN :
- 17917530
- Volume :
- 39
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.doi.dedup.....3684c7273e9cddde054d4f950c5fc117