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Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19
- Source :
- EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The severity of coronavirus disease 2019 (COVID‐19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine‐1‐phosphate (S1P) along with severity markers, in COVID‐19 patients. One hundred eleven COVID‐19 patients and forty‐seven healthy subjects were included. The severity of COVID‐19 was found significantly associated with anemia, lymphocytopenia, and significant increase of neutrophil‐to‐lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C‐reactive protein (CRP), and D‐dimer. Serum S1P level was inversely associated with COVID‐19 severity, being significantly correlated with CRP, LDH, ferritin, and D‐dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient’s outcome. Circulating S1P emerged as negative biomarker of severity/mortality of COVID‐19 patients. Restoring abnormal S1P levels to a normal range may have the potential to be a therapeutic target in patients with COVID‐19.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Medicine (General)
Apolipoprotein B
Anemia
QH426-470
Fibrinogen
Gastroenterology
intensive care unit
sphingosine‐1‐phosphate
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
R5-920
COVID‐19
Internal medicine
Lactate dehydrogenase
medicine
Genetics
prognostic biomarker
biology
business.industry
Albumin
medicine.disease
Ferritin
Coronavirus
030104 developmental biology
chemistry
biology.protein
Molecular Medicine
Biomarker (medicine)
lipids (amino acids, peptides, and proteins)
Lymphocytopenia
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 17574676 and 17574684
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- EMBO Molecular Medicine
- Accession number :
- edsair.doi.dedup.....368cec3c4a9f15872804dfd88fedb288