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Prognostic significance of morphological distribution of metastatic foci in lymph nodes with gastric cancer
- Source :
- Digestive surgery. 28(4)
- Publication Year :
- 2010
-
Abstract
- Background/Aims: The morphological distribution of tumor cells in metastatic lymph nodes has been investigated in positive sentinel lymph nodes in several solid cancers. The aim of this study was to clarify the effect of the distribution of metastatic foci in lymph nodes on the prognosis in gastric cancer. Methods: The distribution of metastatic foci in the 100 node-positive patients who had undergone curative gastrectomy were classified into two groups: (1) massive type, in which the tumor occupied the entire lymph node, and (2) non-massive type, in which the tumor did not occupy the entire lymph node. Results: There were 38 patients in the massive type group and 62 patients in the non-massive type group. The 10-year survival rate was significantly poorer in the massive type group (p = 0.001). Multivariate analysis showed that distributional type and nodal status were independent prognostic factors. UICC N stage was subcategorized by distributional type, and survival was shown to be significantly worse in the massive type in the N1 group (p = 0.035). Conclusion: It seems necessary to take the morphological distribution of metastatic foci into consideration when dealing with node-positive patients who had received curative resection for gastric cancer.
- Subjects :
- Curative resection
Oncology
Male
medicine.medical_specialty
Pathology
Multivariate analysis
Entire lymph node
Kaplan-Meier Estimate
Adenocarcinoma
Stomach Neoplasms
Internal medicine
Nodal status
Medicine
Distribution (pharmacology)
Humans
Neoplasm Invasiveness
Survival rate
Peritoneal Neoplasms
Aged
Neoplasm Staging
Proportional Hazards Models
business.industry
Liver Neoplasms
Gastroenterology
Cancer
Middle Aged
medicine.disease
Prognosis
Lymphatic Metastasis
Multivariate Analysis
Lymph Node Excision
Surgery
Female
Lymph
Lymph Nodes
business
Subjects
Details
- ISSN :
- 14219883
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Digestive surgery
- Accession number :
- edsair.doi.dedup.....36ee55ffeffafeea0bdb768b026a81bf