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HGF/MET and the Immune System: Relevance for Cancer Immunotherapy
- Source :
- International Journal of Molecular Sciences, Vol 19, Iss 11, p 3595 (2018), International Journal of Molecular Sciences
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) axis promotes tumorigenesis and tumor progression in various cancer types. Research data recently evidenced that HGF/MET signaling is also involved also in the immune response, mainly modulating dendritic cells functions. In general, the pathway seems to play an immunosuppressive role, thus hypothesizing that it could constitute a mechanism of primary and acquired resistance to cancer immunotherapy. Recently, some approaches are being developed, including drug design and cell therapy to combine MET and programmed cell death receptor-1 (PD-1)/programmed cell death receptor-ligand 1 (PD-L1) inhibition. This approach could represent a new weapon in cancer therapy in the future.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
Review
medicine.disease_cause
Catalysis
Inorganic Chemistry
Cell therapy
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Immune system
Cancer immunotherapy
Neoplasms
Animals
Humans
Medicine
cancer
HGF
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Hepatocyte Growth Factor
business.industry
Organic Chemistry
Cancer
General Medicine
Immunotherapy
Proto-Oncogene Proteins c-met
medicine.disease
Computer Science Applications
immune system
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Tumor progression
030220 oncology & carcinogenesis
Cancer research
MET
Hepatocyte growth factor
immunotherapy
business
Carcinogenesis
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 19
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....36fb3ee2db505a70548acaf7354ef684