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Asymmetric synthesis of β-substituted γ-lactams via rhodium/diene-catalyzed 1,4-additions: application to the synthesis of (R)-baclofen and (R)-rolipram
- Source :
- Organic letters. 13(4)
- Publication Year :
- 2011
-
Abstract
- An efficient rhodium/diene-catalyzed asymmetric addition of arylboronic acids to α,β-unsaturated γ-lactams has been developed. The power of this methodology is further demonstrated by the concise synthesis of (R)-baclofen and (R)-rolipram.
- Subjects :
- Baclofen
Diene
Molecular Structure
Chemistry
Stereochemistry
Organic Chemistry
Enantioselective synthesis
chemistry.chemical_element
Stereoisomerism
beta-Lactams
Biochemistry
Boronic Acids
Catalysis
Rhodium
chemistry.chemical_compound
medicine
Molecule
(R)-Baclofen
Physical and Theoretical Chemistry
Rolipram
medicine.drug
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 13
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....370835f66acad68854d0a83701a223e0