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Extra virgin olive oil improves post-prandial glycemic and lipid profile in patients with impaired fasting glucose
- Source :
- Clinical Nutrition. 36:782-787
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Extra virgin olive oil (EVOO) improves post-prandial glycaemia in healthy subjects but it has never been investigated if this can be detected in pre-diabetic patients. We investigated if EVOO affects post-prandial glucose and lipid profile in patients with impaired fasting glucose (IFG).Thirty IFG patients were randomly allocated to a meal containing or not 10 g of EVOO in a cross-over design. Before, 60 min and 120 min after lunch a blood sample was taken to measure glucose, insulin, Glucagon-like peptide-1 (GLP1), dipeptidyl-peptidase-4 (DPP4) activity, triglycerides (TG), total cholesterol, HDL-cholesterol and Apo B-48.The meal containing EVOO was associated with a reduction of glucose (p = 0.009) and DPP4 activity (p 0.001) and a significant increase of insulin (p 0.001) and GLP-1 (p 0.001) compared with the meal without EVOO. Furthermore, the meal containing EVOO showed a significant decrease of triglycerides (p = 0.002) and Apo B-48 (p = 0.002) compared with the meal without EVOO. Total cholesterol and HDL cholesterol levels did not significantly change between the two groups.This is the first study to show that in IFG patients EVOO improves post-prandial glucose and lipid profile with a mechanism probably related to incretin up-regulation.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
endocrine system diseases
Mediterranean diet
Dipeptidyl Peptidase 4
medicine.medical_treatment
Incretin
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
Prediabetic State
03 medical and health sciences
0302 clinical medicine
Glucagon-Like Peptide 1
Internal medicine
medicine
Humans
Insulin
In patient
Olive Oil
Triglycerides
Aged
Glycemic
Meal
Cross-Over Studies
Nutrition and Dietetics
diabetes
medicine.diagnostic_test
business.industry
digestive, oral, and skin physiology
nutrition
diet
Fasting
Middle Aged
Postprandial Period
Impaired fasting glucose
medicine.disease
Cholesterol
Endocrinology
Sample Size
Female
Apolipoprotein B-48
business
Lipid profile
Subjects
Details
- ISSN :
- 02615614
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....370a0856feac1ecd5d5d19790db6d669