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Optimization of alcohol precipitation technology of Biqiu granules based on index components and pharmacodynamics
- Source :
- China Journal of Chinese Materia Medica.
- Publication Year :
- 2016
- Publisher :
- China Journal of Chinese Materia Medica, 2016.
-
Abstract
- To evaluate the rationality of alcohol precipitation technology of Biqiu granule by investigating its effect on serum histamine, IgE, IL-4, IFN and TNF-α. The contents of cafferic acid and rosmarinic acid were used as the evaluation indexes, and some factors affecting index were firstly evaluated by Plackett-Burman design; then alcohol precipitation technology was further optimized by Box-Behnken design to determine the optimal alcohol precipitation conditions. The best alcohol precipitation conditions were as follows: the relative density of herb liquor was 1.15 (65 ℃); the concentration of alcohol was 70%, and standing time was 12 hours. Optimal alcohol precipitation technology of Biqiu granules determined by pharmacodynamic screening, Plackett-Burman and Box-Behnken design tests, was stable and feasible with good predictability, providing reliable basis for the industrialization production of Biqiu granules.
- Subjects :
- Operations research
Alcohol
Chemical Fractionation
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Animals
Technology, Pharmaceutical
Pharmacology (medical)
Food science
General Pharmacology, Toxicology and Pharmaceutics
Ethanol
Plackett–Burman design
Tumor Necrosis Factor-alpha
Chemistry
Rosmarinic acid
Granule (cell biology)
Immunoglobulin E
Box–Behnken design
030205 complementary & alternative medicine
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
Pharmacodynamics
Interferons
Interleukin-4
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 10015302
- Database :
- OpenAIRE
- Journal :
- China Journal of Chinese Materia Medica
- Accession number :
- edsair.doi.dedup.....371b1dadb04295275d6dc722adee0f6f