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The pH-dependent reciprocal changes in contributions of ADP/ATP antiporter and aspartate/glutamate antiporter to the fatty acid-induced uncoupling
- Source :
- FEBS Letters. (1):179-182
- Publisher :
- Federation of European Biochemical Societies. Published by Elsevier B.V.
-
Abstract
- The pH effect on carboxyatractylate-, glutamate- and aspartate-induced recoupling of palmitate-uncoupled rat liver mitochondria has been studied. Stimulation of respiration by low palmitate concentrations (5–20 μM) in the presence of 3 mM MgCl2 is shown to be pH-independent within the 7.0–7.8 range. The recoupling effect of glutamate (or aspartate) decreases and that of carboxyatractylate increases with increase in pH. The recoupling effect of a combination of carboxyatractylate and glutamate (aspartate) appears to be constant at these pH values, being as high as about 80%. It is concluded that uncoupling by low palmitate in liver mitochondria is mediated mainly by ATP/ADP and aspartate/glutamate antiporter.
- Subjects :
- endocrine system diseases
Antiporter
Biophysics
Magnesium Chloride
Palmitic Acid
Glutamic Acid
Stimulation
Mitochondria, Liver
Mitochondrion
Atractyloside
Liver mitochondria
Biochemistry
Antiporters
chemistry.chemical_compound
Oxygen Consumption
Structural Biology
Respiration
Genetics
Animals
Recoupler
Molecular Biology
Aspartate/glutamate antiporter
chemistry.chemical_classification
Aspartic Acid
Chemistry
Uncoupling Agents
ATP/ADP antiporter
Carboxyatractylate
Fatty Acids
Glutamate receptor
Fatty acid
nutritional and metabolic diseases
Cell Biology
Hydrogen-Ion Concentration
Rats
EGTA
Aspartate
Uncoupler
ATP–ADP translocase
Glutamate
Mitochondrial ADP, ATP Translocases
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....371d64af2d91be6bfcc6e6a9d3b367e9
- Full Text :
- https://doi.org/10.1016/S0014-5793(97)00667-4