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Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders

Authors :
Nadia Diano
Alfonso Papparella
Stefania Crispi
Luigi Mita
Maria Teresa Piccolo
Ciro Menale
Grazia Cirillo
Raffaele A Calogero
Emanuele Miraglia del Giudice
Damiano Gustavo Mita
Menale, C.
Piccolo, M. T.
Cirillo, G.
Calogero, R. A.
Papparella, A.
Mita, L.
Del Giudice, E. M.
Diano, N.
Crispi, S.
Mita, D. G.
Menale, Ciro
Piccolo, Maria Teresa
Cirillo, Grazia
Calogero, Raffaele A
Papparella, Alfonso
Mita, Luigi
MIRAGLIA DEL GIUDICE, Emanuele
Diano, Nadia
Crispi, Stefania
Mita, Damiano Gustavo
Source :
Journal of molecular endocrinology 54 (2015): 289–303. doi:10.1530/JME-14-0282, info:cnr-pdr/source/autori:Menale, Ciro; Piccolo, Maria Teresa; Cirillo, Grazia; Calogero, Raffaele A; Papparella, Alfonso; Mita, Luigi; Giudice, Emanuele Miraglia Del; Diano, Nadia; Crispi, Stefania; Mita, Damiano Gustavo/titolo:Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders./doi:10.1530%2FJME-14-0282/rivista:Journal of molecular endocrinology/anno:2015/pagina_da:289/pagina_a:303/intervallo_pagine:289–303/volume:54
Publication Year :
2015

Abstract

Bisphenol A (BPA) is a xenobiotic endocrine-disrupting chemical.In vitroandin vivostudies have indicated that BPA alters endocrine-metabolic pathways in adipose tissue, which increases the risk of metabolic disorders and obesity. BPA can affect adipose tissue and increase fat cell numbers or sizes by regulating the expression of the genes that are directly involved in metabolic homeostasis and obesity. Several studies performed in animal models have accounted for an obesogen role of BPA, but its effects on human adipocytes – especially in children – have been poorly investigated. The aim of this study is to understand the molecular mechanisms by which environmentally relevant doses of BPA can interfere with the canonical endocrine function that regulates metabolism in mature human adipocytes from prepubertal, non-obese children. BPA can act as an estrogen agonist or antagonist depending on the physiological context. To identify the molecular signatures associated with metabolism, transcriptional modifications of mature adipocytes from prepubertal children exposed to estrogen were evaluated by means of microarray analysis. The analysis of deregulated genes associated with metabolic disorders allowed us to identify a small group of genes that are expressed in an opposite manner from that of adipocytes treated with BPA. In particular, we found that BPA increases the expression of pro-inflammatory cytokines and the expression ofFABP4andCD36, two genes involved in lipid metabolism. In addition, BPA decreases the expression ofPCSK1, a gene involved in insulin production. These results indicate that exposure to BPA may be an important risk factor for developing metabolic disorders that are involved in childhood metabolism dysregulation.

Details

ISSN :
14796813
Volume :
54
Issue :
3
Database :
OpenAIRE
Journal :
Journal of molecular endocrinology
Accession number :
edsair.doi.dedup.....3726c7d215177b1d41ccf9eed39ad0a1
Full Text :
https://doi.org/10.1530/JME-14-0282