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Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders
- Source :
- Journal of molecular endocrinology 54 (2015): 289–303. doi:10.1530/JME-14-0282, info:cnr-pdr/source/autori:Menale, Ciro; Piccolo, Maria Teresa; Cirillo, Grazia; Calogero, Raffaele A; Papparella, Alfonso; Mita, Luigi; Giudice, Emanuele Miraglia Del; Diano, Nadia; Crispi, Stefania; Mita, Damiano Gustavo/titolo:Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders./doi:10.1530%2FJME-14-0282/rivista:Journal of molecular endocrinology/anno:2015/pagina_da:289/pagina_a:303/intervallo_pagine:289–303/volume:54
- Publication Year :
- 2015
-
Abstract
- Bisphenol A (BPA) is a xenobiotic endocrine-disrupting chemical.In vitroandin vivostudies have indicated that BPA alters endocrine-metabolic pathways in adipose tissue, which increases the risk of metabolic disorders and obesity. BPA can affect adipose tissue and increase fat cell numbers or sizes by regulating the expression of the genes that are directly involved in metabolic homeostasis and obesity. Several studies performed in animal models have accounted for an obesogen role of BPA, but its effects on human adipocytes – especially in children – have been poorly investigated. The aim of this study is to understand the molecular mechanisms by which environmentally relevant doses of BPA can interfere with the canonical endocrine function that regulates metabolism in mature human adipocytes from prepubertal, non-obese children. BPA can act as an estrogen agonist or antagonist depending on the physiological context. To identify the molecular signatures associated with metabolism, transcriptional modifications of mature adipocytes from prepubertal children exposed to estrogen were evaluated by means of microarray analysis. The analysis of deregulated genes associated with metabolic disorders allowed us to identify a small group of genes that are expressed in an opposite manner from that of adipocytes treated with BPA. In particular, we found that BPA increases the expression of pro-inflammatory cytokines and the expression ofFABP4andCD36, two genes involved in lipid metabolism. In addition, BPA decreases the expression ofPCSK1, a gene involved in insulin production. These results indicate that exposure to BPA may be an important risk factor for developing metabolic disorders that are involved in childhood metabolism dysregulation.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
medicine.drug_class
CD36
Adipose tissue
Context (language use)
adipocytes
bisphenol A
children
gene expression
metabolic homeostasis
Endocrine Disruptors
Bisphenol A
Endocrinology
Metabolic Diseases
Phenols
Internal medicine
Gene expression
Insulin Secretion
medicine
Adipocytes
Humans
Insulin
Benzhydryl Compounds
gene
Child
Children
Molecular Biology
Cells, Cultured
Adipocyte
biology
Estradiol
urogenital system
Microarray analysis techniques
Bisphenol
Lipid metabolism
metabolic disorders
Lipid Metabolism
Estrogen
biology.protein
Female
Transcriptome
hormones, hormone substitutes, and hormone antagonists
Obesogen
Metabolic homeostasis
Subjects
Details
- ISSN :
- 14796813
- Volume :
- 54
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of molecular endocrinology
- Accession number :
- edsair.doi.dedup.....3726c7d215177b1d41ccf9eed39ad0a1
- Full Text :
- https://doi.org/10.1530/JME-14-0282