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Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer: Meta-analysis using Mendelian randomization
- Source :
- The Journal of International Medical Research
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- Objectives To undertake a systematic meta-analysis of all variants in the gene encoding receptor for advanced glycation end products ( RAGE) to summarize their associations with cancer risk and changes in the levels of circulating soluble RAGE (sRAGE), with the aim of determining possible causality between circulating sRAGE and cancer risk. Methods Articles written in English were retrieved from MEDLINE® and EMBASE® databases. Two researchers independently identified eligible articles and extracted the data (analysed using STATA® software version 12.0). Results Fifteen articles qualified for inclusion in the meta-analysis of the RAGE–cancer association and three examined the RAGE–sRAGE relationship. The 82Ser/82Ser genotype was significantly associated with overall cancer risk compared with the 82Gly/Gly genotype (odds ratio 1.75, 95% confidence interval [CI] 1.46, 2.10). Carriers of the 82Ser/82Ser genotype had significantly reduced circulating sRAGE concentrations compared with the 82Gly/82Gly genotype. Mendelian randomization analysis demonstrated that a reduction of 100, 200 and 300 pg/ml in circulating sRAGE concentrations was associated with a 1.11-fold (95% CI 1.06, 1.25), 1.24-fold (95% CI 1.11, 1.57) and 1.38-fold (95% CI 1.18, 1.96) increased risk of developing cancer, respectively. Conclusions Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer.
- Subjects :
- 0301 basic medicine
Oncology
Male
Risk
medicine.medical_specialty
Heterozygote
Genotype
Receptor for Advanced Glycation End Products
Gene Expression
Bioinformatics
Biochemistry
RAGE (receptor)
03 medical and health sciences
0302 clinical medicine
Internal medicine
Neoplasms
Mendelian randomization
Biomarkers, Tumor
Odds Ratio
Medicine
cancer
Humans
Receptor for advanced glycation end products (RAGE)
Polymorphism, Genetic
business.industry
Biochemistry (medical)
Cancer
Mendelian Randomization Analysis
Cell Biology
General Medicine
Odds ratio
medicine.disease
Confidence interval
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
Female
business
Meta-Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 14732300 and 03000605
- Volume :
- 44
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....3728f7b50fa1c721bc5bc5a976e2d784