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Patch grafting of organoids of stem/progenitors into solid organs can correct genetic-based disease states
- Publication Year :
- 2022
- Publisher :
- ELSEVIER SCI LTD, 2022.
-
Abstract
- Patch grafting, a novel strategy for transplantation of stem/progenitor organoids into porcine livers, has been found successful also for organoid transplantation into other normal or diseased solid organs in pigs and mice. Each organoid contained ∼100 cells comprised of biliary tree stem cells (BTSCs), co-hepato/pancreatic stem/progenitors, and partnered with early lineage stage mesenchymal cells (ELSMCs), angioblasts and precursors to endothelia and stellate cells. Patch grafting enabled transplantation into livers or pancreases of ≥10
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....374d919ae98eef2cb44fe6e42d8a84da