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Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
- Source :
- CELL, Cell
- Publication Year :
- 2021
- Publisher :
- Cell Press, 2021.
-
Abstract
- Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the UK to accelerate population coverage with a single dose. At this time, trial data was lacking, and we addressed this in a study of UK healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a sub-study of 589 individuals, we show that this single dose induces SARS-CoV-2 neutralizing antibody (NAb) responses and a sustained B and T cell response to spike protein. NAb levels were higher after the extended dosing interval (6-14 weeks) compared to the conventional 3-4 week regimen, accompanied by enrichment of CD4+ T cells expressing IL2. Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective, immunogenic protocol.<br />After giving a primary dose, delaying administration of a second dose of BNT162b2 COVID-19 vaccine up to 6-14 weeks continues to provide strong protection and contributes to favorable antibody, B cell, and T cell responses.
- Subjects :
- Adult
Male
COVID-19 Vaccines
T-Lymphocytes
Population
Dose-Response Relationship, Immunologic
Antibodies, Viral
Article
General Biochemistry, Genetics and Molecular Biology
Young Adult
Cross-Priming
Immunity
Ethnicity
medicine
Humans
Dosing
education
Neutralizing antibody
BNT162 Vaccine
B cell
Aged
Vaccines, Synthetic
education.field_of_study
biology
SARS-CoV-2
Immunogenicity
COVID-19
Middle Aged
Reference Standards
Antibodies, Neutralizing
Regimen
Treatment Outcome
medicine.anatomical_structure
Immunoglobulin G
Immunology
Linear Models
biology.protein
Female
Antibody
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Database :
- OpenAIRE
- Journal :
- CELL, Cell
- Accession number :
- edsair.doi.dedup.....3759990625e1d7316179914d2a3269e4