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Association Study Between SLC15A4 Polymorphisms and Haplotypes and Systemic Lupus Erythematosus in a Han Chinese Population
- Source :
- Genetic Testing and Molecular Biomarkers
- Publication Year :
- 2016
- Publisher :
- Mary Ann Liebert, Inc., 2016.
-
Abstract
- Objective: The gene SLC15A4 (solute carrier family 15 [oligopeptide transporter], member 4) has been reported as contributing to the pathogenesis of systemic lupus erythematosus (SLE). We performed a case–control replication study to investigate further the association between single-nucleotide polymorphisms (SNPs) in the SLC15A4 gene and systemic SLE in a Han Chinese population. Methods: In Han Chinese SLE patients and healthy individuals (n = 355, 375, respectively), 18 SNPs in the SLC15A4 gene were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and TaqMan SNP genotyping assays. Analyses of allele frequencies and genotypes using codominant, dominant, and recessive models were conducted, as well as a linkage disequilibrium analysis. P values
- Subjects :
- 0301 basic medicine
Adult
Male
Linkage disequilibrium
China
Single-nucleotide polymorphism
Nerve Tissue Proteins
Biology
Polymorphism, Single Nucleotide
Linkage Disequilibrium
03 medical and health sciences
0302 clinical medicine
Asian People
Gene Frequency
immune system diseases
medicine
Ethnicity
Humans
Lupus Erythematosus, Systemic
Genetic Predisposition to Disease
Allele
skin and connective tissue diseases
Allele frequency
Genetics (clinical)
Alleles
Genetics
Lupus erythematosus
Haplotype
Membrane Transport Proteins
General Medicine
Original Articles
Middle Aged
medicine.disease
SNP genotyping
Genotype frequency
030104 developmental biology
Haplotypes
030220 oncology & carcinogenesis
Case-Control Studies
Female
Carrier Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 19450257 and 19450265
- Volume :
- 20
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Genetic Testing and Molecular Biomarkers
- Accession number :
- edsair.doi.dedup.....37705ac1eab2155d896488df2b8acb22