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Differential immune responses of C57BL/6 mice to infection by Salmonella enterica serovar Typhimurium strain SL1344, CVCC541 and CMCC50115
- Source :
- Virulence, Vol 10, Iss 1, Pp 248-259 (2019), Virulence
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- With a broad range of hosts, Salmonella enterica serovar Typhimurium (S. Typhimurium) is the major cause of gastroenteritis in human beings and systemic disease in susceptible mice strains. However, different S. Typhimurium strains differ in regard to virulence and host adaptation. Here, C57BL/6 mice were infected, respectively, with different S. Typhimurium strains SL1344 (calf), CVCC541 (chicken) and CMCC50115 (mutton) to determine their virulence and host immune responses. It was found that mice were less susceptible to infection by S. Typhimurium CVCC541 and CMCC50115 strains, with lower lethality and decreased bacterial burden in liver and spleen. Besides, S. Typhimurium strains CVCC541 and CMCC50115 enhanced host innate immune responses by increased frequencies of macrophages and neutrophils 3 days after infection. But SL1344 strain evaded immune response by inducing apoptosis of macrophages. Moreover, CVCC541 could elicit adaptive immune responses of host 11 days after infection upon examination of the proliferation and activation of CD4+ T cells. In addition, 125 and 138 unique mutant coding genes, respectively, in S. Typhimurium strains CVCC541 and CMCC50115 and 78 shared mutant coding genes were annotated by genomic alignment to SL1344 genome and the signal pathways involving these genes were further analyzed. The acquired results indicate that different original S. Typhimurium strains show differential virulence and may induce diverse immune responses in the same host infected.
- Subjects :
- Microbiology (medical)
Serotype
mice
salmonella enterica serovar typhimurium
T-Lymphocytes
Immunology
Antigen-Presenting Cells
Virulence
Spleen
Biology
Microbiology
immune response
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Immune system
Species Specificity
medicine
Animals
lcsh:RC109-216
Gene
030304 developmental biology
Salmonella Infections, Animal
0303 health sciences
Innate immune system
030306 microbiology
Genetic Variation
Salmonella enterica
biology.organism_classification
Immunity, Innate
Mice, Inbred C57BL
virulence
Infectious Diseases
medicine.anatomical_structure
Mutation
bacteria
Female
Parasitology
Host adaptation
Research Paper
Subjects
Details
- ISSN :
- 21505608 and 21505594
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Virulence
- Accession number :
- edsair.doi.dedup.....37e6fac9588ebccf1fd7955e8abf5d33