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In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer. Inbred mice exhibit identical intra-strain genetics and divergent inter-strain phenotypes. The cognitive and behavioral divergences must be controlled by the variances of structure and function of their brains; however, the underlying morphological features of strain-to-strain difference remain obscure. Here, in vivo microscopic magnetic resonance imaging was optimized to image the mouse brains by using an isotropic resolution of 80 μm. Next, in vivo templates were created from the data from four major inbred mouse strains (C57Bl/6, BALB/cBy, C3H/He, and DBA/2). A strain-mixed brain template was also created, and the template was then employed to establish automatic voxel-based morphometry (VBM) for the mouse brain. The VBM assessment revealed strain-specific brain morphologies concerning the gray matter volume of the four strains, with a smaller volume in the primary visual cortex for the C3H/He strain, and a smaller volume in the primary auditory cortex and field CA1 of the hippocampus for the DBA/2 strain. These findings would contribute to the basis of for understanding morphological phenotype of the inbred mouse strain and may indicate a relationship between brain morphology and strain-specific cognition and behavior.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Intravital Microscopy
Science
Biology
computer.software_genre
Auditory cortex
Article
030218 nuclear medicine & medical imaging
Mice
03 medical and health sciences
0302 clinical medicine
Species Specificity
Voxel
In vivo
Image Processing, Computer-Assisted
medicine
Animals
Gray Matter
Visual Cortex
Auditory Cortex
Mice, Inbred BALB C
Mice, Inbred C3H
Multidisciplinary
medicine.diagnostic_test
Brain morphometry
Brain
Magnetic resonance imaging
Voxel-based morphometry
Magnetic Resonance Imaging
Phenotype
Mice, Inbred C57BL
Visual cortex
medicine.anatomical_structure
Mice, Inbred DBA
Medicine
computer
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....37eb3881f3c8ad66ada64968120156d8