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Detecting Change Using Standard Global Perimetric Indices in Glaucoma
- Source :
- American Journal of Ophthalmology. 176:148-156
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Purpose Various global indices are available to summarize results from standard automated perimetry. This study asks which index can detect significant deterioration earliest, for a fixed specificity. Design Comparison of prognostic indices. Methods Two cohorts were tested. A test-retest cohort contained 5 reliable visual fields, within a short interval, from 45 eyes of 23 participants with glaucoma and/or likelihood of developing glaucoma. A separate longitudinal cohort contained 508 eyes from 330 participants, tested on average 13 times. Three global indices were extracted: mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI). For each index we defined a critical P value Crit Index , such that 5% of test-retest series showed significant deterioration with P Index , using artificial "test dates" in random order. Therefore these criteria have 95% specificity over series of 5 tests. The times to detect significant deterioration in the longitudinal cohort were compared using a survival analysis model. Results The median time to detect significant deterioration with MD was 7.3 years (95% confidence interval [CI] 6.8–7.9 years). For VFI, the median was 8.5 years (95% CI 7.9–9.0 years); this comparison had P = .088. For PSD, the median was 10.5 years (95% CI 9.3–11.7 years), slower than MD with P P = .0013) and 107 for PSD ( P = .029). Conclusions MD detected significant deterioration sooner than VFI or PSD. In particular, MD detected more eyes in the first 5 years of their follow-up, which were presumably undergoing more rapid progression.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Time Factors
Vision Disorders
Glaucoma
Article
03 medical and health sciences
0302 clinical medicine
Pattern standard deviation
Ophthalmology
Statistics
Humans
Medicine
Longitudinal cohort
Survival analysis
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Reproducibility of Results
Retrospective cohort study
Middle Aged
medicine.disease
Confidence interval
Visual field
030104 developmental biology
Cohort
Disease Progression
030221 ophthalmology & optometry
Visual Field Tests
Female
Visual Fields
business
Glaucoma, Open-Angle
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029394
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- American Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....382733c27350e065d98930caee31d1fa