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Novel avian-origin human influenza A(H7N9) can be transmitted between ferrets via respiratory droplets
- Source :
- The Journal of infectious diseases. 209(4)
- Publication Year :
- 2013
-
Abstract
- The outbreak of human infections caused by novel avian-origin influenza A(H7N9) in China since March 2013 underscores the need to better understand the pathogenicity and transmissibility of these viruses in mammals. In a ferret model, the pathogenicity of influenza A(H7N9) was found to be less than that of an influenza A(H5N1) strain but comparable to that of 2009 pandemic influenza A(H1N1), based on the clinical signs, mortality, virus dissemination, and results of histopathologic analyses. Influenza A(H7N9) could replicate in the upper and lower respiratory tract, the heart, the liver, and the olfactory bulb. It is worth noting that influenza A(H7N9) exhibited a low level of transmission between ferrets via respiratory droplets. There were 4 mutations in the virus isolated from the contact ferret: D678Y in the gene encoding PB2, R157K in the gene encoding hemagglutinin (H3 numbering), I109T in the gene encoding nucleoprotein, and T10I in the gene encoding neuraminidase. These data emphasized that avian-origin influenza A(H7N9) can be transmitted between mammals, highlighting its potential for human-to-human transmissibility.
- Subjects :
- Hemagglutinin (influenza)
medicine.disease_cause
Influenza A Virus, H7N9 Subtype
Virus
Orthomyxoviridae Infections
Pandemic
medicine
Immunology and Allergy
Animals
Lung
Administration, Intranasal
biology
Transmission (medicine)
Body Weight
Ferrets
virus diseases
Outbreak
Environmental Exposure
Virology
Influenza A virus subtype H5N1
Nucleoprotein
Disease Models, Animal
Infectious Diseases
biology.protein
Pharynx
Nasal Cavity
Neuraminidase
Subjects
Details
- ISSN :
- 15376613
- Volume :
- 209
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....38281905492089e54eed108c758a8c55