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Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia
- Source :
- BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-10 (2020), BMC Pulmonary Medicine
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Background Non–small-cell lung cancer (NSCLC) has been reported to develop in patients with interstitial pneumonia (IP); however, clinical, radiological, and pathological features remain to be elucidated. Methods We retrieved the records of 120 consecutive NSCLC patients associated with IP who underwent surgery at Toranomon Hospital between June 2011 and May 2017. We classified the patients into three groups according to NSCLC location using high-resolution computed tomography: group A, within a fibrotic shadow and/or at the interface of a fibrotic shadow and normal lung; group B, within emphysematous tissue and/or at the interface of emphysematous tissue and normal lung; and group C, within normal lung. In 64 patients, programmed death ligand-1 (PD-L1) status was assessed with immunohistostaining. Results Most of the patients (89; 70%) were classified as group A. This group tended to have squamous cell carcinoma with the usual interstitial pneumonia (UIP). These cancers were located mainly in the lower lobes and seven of the eight postoperative acute exacerbations (pAE) of IP developed in this group. NSCLC in the group B were mainly squamous cell carcinomas located in the upper lobes. No patient with PD-L1 negative was classified into group B. None of the patients in group C showed UIP. and most of the cancers were adenocarcinoma. The frequency of epidermal growth factor receptor mutation-positive NSCLC was the highest in this group. Conclusions The three groups each showed characteristic features in terms of tumor location, histopathology, PD-L1 expression, and frequency of pAEof IP.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Pulmonary emphysema
Lung Neoplasms
Databases, Factual
Video-assisted thoracic surgery
Interstitial lung disease
Gastroenterology
B7-H1 Antigen
Group B
Japan
Usual interstitial pneumonia
Carcinoma, Non-Small-Cell Lung
Internal medicine
medicine
Humans
Pneumonectomy
Lung cancer
Pathological
Aged
Retrospective Studies
Aged, 80 and over
Postoperative Care
lcsh:RC705-779
Thoracic Surgery, Video-Assisted
business.industry
Non–small-cell lung cancer
Cancer
lcsh:Diseases of the respiratory system
Middle Aged
medicine.disease
Immunohistochemistry
Survival Analysis
respiratory tract diseases
Acute exacerbation
Disease Progression
Adenocarcinoma
Female
Histopathology
Lung Diseases, Interstitial
Tomography, X-Ray Computed
business
Cancer location
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712466
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Pulmonary Medicine
- Accession number :
- edsair.doi.dedup.....3829ea90e52a5bcea59c3e87126cbc5b