Back to Search
Start Over
High prevalence of hepatitis E in humans and pigs and evidence of genotype-3 virus in swine, Madagascar
- Source :
- American Journal of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 88 (2), pp.329--338. ⟨10.4269/ajtmh.2012.12-0615⟩
- Publication Year :
- 2013
-
Abstract
- International audience; Hepatitis E virus (HEV) causes an orofecal disease transmitted through poor hygiene environments, contaminated food (mainly pork products), or by contacts with infected animals. Very little data are currently available regarding the disease in the Southwestern Indian Ocean Islands. We report the first sero- and viro-survey for HEV in human and swine in Madagascar. A seroprevalence rate of 14.1% (60 of 427) was measured in slaughterhouse workers. Seroprevalence to HEV in pigs was estimated to 71.2% (178 of 250), strongly suggesting the existence of a zoonotic cycle. Three out of 250 pig livers (1.2%) tested HEV RNA-positive by quantitative polymerase chain reaction. Phylogenetic analyses based on 1-kb sequences of the ORF 2-3 identified these viruses as HEV genotype 3. Sequences clustered in a distinct Malagasy sub-clade, possibly representative of a new sub-genotype, for which the date of emergence was estimated around 1989. Further studies are needed to confirm other transmission routes of HEV to humans, especially through non-zoonotic cycles.
- Subjects :
- Male
Swine
Virologie
Travailleur
Antibodies, Viral
Polymerase Chain Reaction
law.invention
MESH: Genotype
0302 clinical medicine
Porcin
Seroepidemiologic Studies
Analyse du risque
MESH: Animals
MESH: Phylogeny
MESH: Swine
Phylogeny
MESH: Meat
0303 health sciences
MESH: Middle Aged
virus diseases
3. Good health
MESH: Young Adult
MESH: RNA, Viral
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Hépatite
Génotype
Genre humain
Genotype
03 medical and health sciences
MESH: Cross-Sectional Studies
Phylogenetics
Hepatitis E virus
Madagascar
Humans
MESH: Indian Ocean Islands
MESH: Prevalence
MESH: Seroepidemiologic Studies
MESH: Humans
MESH: Adult
MESH: Polymerase Chain Reaction
medicine.disease
Virology
Cross-Sectional Studies
Parasitology
MESH: Female
Danger pour la santé
MESH: Antibodies, Viral
MESH: Liver
MESH: Abattoirs
Identification
MESH: Sequence Analysis, DNA
MESH: Swine Diseases
[SDV]Life Sciences [q-bio]
viruses
medicine.disease_cause
L73 - Maladies des animaux
MESH: Madagascar
law
Prevalence
Polymerase chain reaction
2. Zero hunger
Swine Diseases
Transmission (medicine)
Articles
Middle Aged
Hepatitis E
Infectious Diseases
Liver
S50 - Santé humaine
RNA, Viral
Female
Abattoir
Abattoirs
zoonose
Adult
MESH: Hepatitis E virus
Séquence nucléotidique
Meat
030231 tropical medicine
Biology
Virus
Sérologie
Young Adult
Indian Ocean Islands
medicine
Seroprevalence
Animals
Transmission des maladies
030304 developmental biology
MESH: Hepatitis E
Sequence Analysis, DNA
MESH: Male
Enquête pathologique
Subjects
Details
- Language :
- English
- ISSN :
- 00029637
- Database :
- OpenAIRE
- Journal :
- American Journal of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 88 (2), pp.329--338. ⟨10.4269/ajtmh.2012.12-0615⟩
- Accession number :
- edsair.doi.dedup.....382de36c6576338f68abfeaa2a3ee6c3