Supplementary Figure 1 from Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features

PDF file - 180K, A, Growth rate of MDA PCA 144-13, 146-10, 155-2, 170-4 and 180-30 xenografts. Note that the MDA PCA 144-13 xenograft line displays a large amount of necrosis. B. Diagram illustrates unsupervised hierarchal clustering using complete linkage and Pearson's correlation coefficient analysis of the raw expression profiles of androgen receptor-positive adenocarcinoma (MDA PCA 130, 117-9, 79) and androgen receptor-negative SCPC/LCNEC (MDA PCA 146-10, 155-2, 155-12, 144-13, 144-4) xenografts obtained with Affymetrix HGU133Plus2 array. In red are samples assessed on 1 day and in blue, those assessed on a different day. B, diagram illustrates Gene Ontology analysis results showing enrichment in biologic-process subtrees related to mitosis among the differently expressed genes. The biological processes that reached statistical significance are highlighted in red. SCPC, small-cell prostate carcinoma; LCNEC, large-cell neuroendocrine carcinoma.