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Molecular target interactions of quinoline derivatives as anticancer agents: A review

Authors :
Vikas Pradhan
Salahuddin
Rajnish Kumar
Avijit Mazumder
Mohammad Mustaqeem Abdullah
Mohammad Shahar Yar
Mohamed Jawed Ahsan
Zabih Ullah
Source :
Chemical Biology & Drug Design. 101:977-997
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

One of the leading causes of death worldwide is cancer, which poses substantial risks to both society and an individual's life. Cancer therapy is still challenging, despite developments in the field and continued research into cancer prevention. The search for novel anticancer active agents with a broader cytotoxicity range is therefore continuously ongoing. The benzene ring gets fused to a pyridine ring at two carbon atoms close to one another to form the double ring structure of the heterocyclic aromatic nitrogen molecule known as quinoline (1-azanaphthalene). Quinoline derivatives contain a wide range of pharmacological activities, including antitubercular, antifungal, antibacterial, and antimalarial properties. Quinoline derivatives have also been shown to have anticancer properties. There are many quinoline derivatives widely available as anticancer drugs that act via a variety of mechanisms on various molecular targets, such as inhibition of topoisomerase, inhibition of tyrosine kinases, inhibition of heat shock protein 90 (Hsp90), inhibition of histone deacetylases (HDACs), inhibition of cell cycle arrest and apoptosis, and inhibition of tubulin polymerization.

Details

ISSN :
17470285 and 17470277
Volume :
101
Database :
OpenAIRE
Journal :
Chemical Biology & Drug Design
Accession number :
edsair.doi.dedup.....38823a1697d0737476139b2bada811bb
Full Text :
https://doi.org/10.1111/cbdd.14196