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Distinct genotype and antigenicity among genogroup II sapoviruses
- Source :
- Microbiology and Immunology. 53:417-420
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- SaV, a pathogen of acute gastroenteritis, is divided into five genogroups, GI to GV. However, the relation between SaV antigenicity and genetic clusters is not fully understood. We have recently identified two GII SaV strains, Mc10 and C12, which are grouped into the same cluster based on the polymerase but are grouped into distinct clusters based on the capsid. To evaluate the difference in antigenicity between these two strains, VLP were expressed in mammalian cells. An antigen ELISA demonstrated for the first time that strains in the same GII SaV genogroup, but within different clusters, have distinct antigenicities.
- Subjects :
- Antigenicity
Genotype
viruses
Guinea Pigs
Immunology
Enzyme-Linked Immunosorbent Assay
Transfection
Microbiology
Sapovirus
fluids and secretions
Virology
Chlorocebus aethiops
Animals
Antigens, Viral
Pathogen
Polymerase
Caliciviridae Infections
biology
Capture elisa
Immune Sera
Virion
virus diseases
biology.organism_classification
Gastroenteritis
Capsid
COS Cells
biology.protein
Rabbits
Cluster based
Subjects
Details
- ISSN :
- 13480421 and 03855600
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Microbiology and Immunology
- Accession number :
- edsair.doi.dedup.....388da6ab7ca0287ae74514418787c8a6
- Full Text :
- https://doi.org/10.1111/j.1348-0421.2009.00133.x