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A community study of clinical traits and risk factors for human metapneumovirus and respiratory syncytial virus infection during the first year of life
- Source :
- European Journal of Pediatrics
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are important respiratory pathogens with similar symptomatology. The aim of this prospective birth cohort study was to identify risk factors for an hMPV or RSV infection during the first year of life in unselected healthy children. We followed 217 children from birth to 1 year of age. Nasal swabs and symptom diaries were collected monthly. Anti-hMPV and anti-RSV IgG antibodies by age 1 year were detected by ELISA, and nasal swabs were analysed for hMPV and RSV by RT-PCR. Logistic regression was used for risk factor analysis. Anti-hMPV IgG was found in 38 children (17.5%), and anti-RSV IgG in 172 children (79%). Risk factors for being anti-hMPV IgG-positive were: (1) being born in the spring (OR = 2.36; 95% CI:1.06–5.27), and (2) having older siblings (OR = 3.82; 95% CI:1.75–8.34). Risk factors for being anti-RSV IgG-positive were: (1) gestational age
- Subjects :
- Male
medicine.medical_specialty
Pediatrics
viruses
Enzyme-Linked Immunosorbent Assay
Gestational Age
Respiratory Syncytial Virus Infections
Antibodies, Viral
Cohort Studies
Human metapneumovirus
Risk Factors
Epidemiology
medicine
Humans
Prospective Studies
Risk factor
Prospective cohort study
Children
Original Paper
Paramyxoviridae Infections
biology
Reverse Transcriptase Polymerase Chain Reaction
business.industry
Infant, Newborn
Infant
RSV
virus diseases
Gestational age
biology.organism_classification
Respiratory Syncytial Viruses
Birth order
Breast Feeding
Immunoglobulin G
Pediatrics, Perinatology and Child Health
Female
Tobacco Smoke Pollution
Metapneumovirus
Seasons
Birth Order
business
Infants
Breast feeding
Cohort study
Subjects
Details
- ISSN :
- 14321076 and 03406199
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- European Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....3891442cc80c6b035a0840176a10aa98