Back to Search
Start Over
Antiâphospholipid antibodies and reproductive failures
- Source :
- American Journal of Reproductive Immunology. 85
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Anti-phospholipid syndrome (APS) recapitulates the link between autoimmunity and pregnancy failure: Acquired anti-phospholipid antibodies (aPL) play a pathogenic role in pregnancy complications. The diagnosis of obstetric APS can easily be pursued when women present with laboratory and clinical features fulfilling the international classification criteria. Standard therapeutic approach to obstetric APS consists in the association of anti-platelet agents and anticoagulants. Most patients achieve a live birth thanks to conventional treatment; however, approximately 20% fail to respond and are managed with additional therapeutic tools added on the top of conventional treatment. Surely, a refinement of risk stratification tools would allow early identification of high-risk pregnancies that warrant tailored treatment. In real life, obstetricians and rheumatologists face complex diagnostic scenarios including women with pregnancy morbidities other than those mentioned in classification criteria such as one or two early losses and premature birth after 34 weeks due to preeclampsia or placental insufficiency, women with low-titer aPL not fulfilling criteria laboratory requirements, women with positive non-criteria aPL, asymptomatic aPL carriers, and infertile women found to be aPL-positive. This review focuses on some of the several unanswered questions related to diagnostic, prognostic, and therapeutic aspects in obstetric APS.
- Subjects :
- medicine.medical_specialty
Immunology
Placental insufficiency
Asymptomatic
Preeclampsia
Therapeutic approach
Pregnancy
medicine
Animals
Humans
Immunology and Allergy
Intensive care medicine
business.industry
Pregnancy Outcome
Obstetrics and Gynecology
medicine.disease
Anti phospholipid antibodies
Reproductive Medicine
Premature birth
Antibodies, Antiphospholipid
Female
medicine.symptom
Live birth
business
Infertility, Female
Subjects
Details
- ISSN :
- 16000897 and 10467408
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- American Journal of Reproductive Immunology
- Accession number :
- edsair.doi.dedup.....38b1fe5769b8a1fcf49755ab0ea41bb1