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Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces
- Source :
- Molecules; Volume 21; Issue 2; Pages: 220, Molecules, Molecules, Vol 21, Iss 2, p 220 (2016)
- Publication Year :
- 2016
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2016.
-
Abstract
- Deposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections.<br />Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI; European Union (EU)
- Subjects :
- 0301 basic medicine
Scanning electron microscope
Pharmaceutical Science
Organic chemistry
02 engineering and technology
Analytical Chemistry
Mice
Coated Materials, Biocompatible
X-Ray Diffraction
Drug Discovery
Microscopy
Cefepime
Maple
zinc oxide
Adhesion
021001 nanoscience & nanotechnology
cyclodextrins
drug delivery
MAPLE
modified surface
biofilm inhibition
Anti-Bacterial Agents
Chemistry (miscellaneous)
Cyclodextrins
Zinc oxide
Drug delivery
Modified surface
Biofilm inhibition
Molecular Medicine
0210 nano-technology
Materials science
Biocompatibility
030106 microbiology
chemistry.chemical_element
Nanotechnology
Zinc
engineering.material
Article
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
Animals
Physical and Theoretical Chemistry
Organic Chemistry
Biofilm
bacterial infections and mycoses
Evaporation (deposition)
Cephalosporins
Nanostructures
Chemical engineering
chemistry
Biofilms
engineering
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules; Volume 21; Issue 2; Pages: 220
- Accession number :
- edsair.doi.dedup.....38be9d3937a63c682ffab8e4834911ae
- Full Text :
- https://doi.org/10.3390/molecules21020220