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Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity
- Source :
- Vaccine. 37(24)
- Publication Year :
- 2018
-
Abstract
- In conjugate, inactivated, recombinant, and toxoid vaccines, adjuvants are extensively and essentially used for enhanced and long-lasting protective immune responses. Depending on the type of diseases and immune responses required, adjuvants with different design strategies are developed. With aluminum salt-based adjuvants as the most used ones in commercial vaccines, other limited adjuvants, e.g., AS01, AS03, AS04, CpG ODN, and MF59, are used in FDA-approved vaccines for human use. In this paper, we review the uses of different adjuvants in vaccines including the ones used in FDA-approved vaccines and vaccines under clinical investigations. We discuss how adjuvants with different formulations could affect the magnitude and quality of adaptive immune response for optimized protection against specific pathogens. We emphasize the molecular mechanisms of various adjuvants, with the aim to establish structure-activity relationships (SARs) for designing more effective and safer adjuvants for both preventative and therapeutic vaccines.
- Subjects :
- Squalene
CpG Oligodeoxynucleotide
medicine.medical_treatment
030231 tropical medicine
alpha-Tocopherol
MF59
Polysorbates
Adaptive Immunity
03 medical and health sciences
Structure-Activity Relationship
0302 clinical medicine
Immune system
Immunogenicity, Vaccine
Adjuvants, Immunologic
Adjuvanticity
medicine
Animals
Humans
030212 general & internal medicine
Clinical Trials as Topic
Vaccines
General Veterinary
General Immunology and Microbiology
business.industry
Immunogenicity
Public Health, Environmental and Occupational Health
Toxoid
Acquired immune system
Drug Combinations
Infectious Diseases
Immunology
Molecular Medicine
business
Adjuvant
Subjects
Details
- ISSN :
- 18732518
- Volume :
- 37
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....38ef2ff8fe5ae12e315330abb0e82238