Back to Search Start Over

Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium

Authors :
Marta Vilensky
Joshua E. Muscat
Thomas L. Vaughan
Mark P. Purdue
Hal Morgenstern
Gypsyamber D'Souza
Paolo Boffetta
Stephen M. Schwartz
Richard B. Hayes
Mia Hashibe
Chu Chen
Robert I. Haddad
Yuan-Chin Amy Lee
Deborah M. Winn
Stimson P. Schantz
Carlo La Vecchia
Xavier Castellsagué
Sergio Koifman
Ana M. B. Menezes
Victor Wünsch-Filho
Leticia Fernandez
Guo-Pei Yu
Samantha Sartori
Maura L. Gillison
Alexander W. Daudt
Andrew F. Olshan
Maria Paula Curado
Zuo-Feng Zhang
Boffetta, P.
Hayes, R.B.
Sartori, S.
Lee, Y.-C.A.
Muscat, J.
Olshan, A.
Winn, D.M.
Castellsagué, X.
Zhang, Z.-F.
Morgenstern, H.
Chen, C.
Schwartz, S.M.
Vaughan, T.L.
Wunsch-Filho, V.
Purdue, M.
Koifman, S.
Curado, M.P.
Vilensky, M.
Gillison, M.
Fernandez, L.
Menezes, A.
Daudt, A.W.
Schantz, S.
Yu, G.
D'Souza, G.
Haddad, R.I.
La Vecchia, C.
Hashibe, M.
Source :
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), vol 25, iss 4, Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona
Publication Year :
2015

Abstract

Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10 090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 [95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend

Details

ISSN :
14735709
Volume :
25
Issue :
4
Database :
OpenAIRE
Journal :
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
Accession number :
edsair.doi.dedup.....38faba1f9a85117fd154e63847406ed0