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Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium
- Source :
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), vol 25, iss 4, Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2015
-
Abstract
- Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10 090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 [95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend
- Subjects :
- Larynx
Male
Cancer Research
Epidemiology
Mouthwashes
Dentistry
pharyngeal cancer
Oral and gastrointestinal
Substance Misuse
0302 clinical medicine
Risk Factors
Prevalence
Càncer de cap
Cancer
alcohol
mouthwash
Prognosis
medicine.anatomical_structure
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Public Health and Health Services
laryngeal cancer
Female
Adult
medicine.medical_specialty
Oncology and Carcinogenesis
Head cancer
03 medical and health sciences
stomatognathic system
Meta-Analysis as Topic
Internal medicine
Tobacco
medicine
otorhinolaryngologic diseases
Humans
Oncology & Carcinogenesis
Dental/Oral and Craniofacial Disease
Retrospective Studies
Tobacco Smoke and Health
business.industry
Prevention
Head and neck cancer
Public Health, Environmental and Occupational Health
Case-control study
International Agencies
Retrospective cohort study
030206 dentistry
Odds ratio
oral cancer
medicine.disease
Neck cancer
Confidence interval
Càncer de coll
stomatognathic diseases
Good Health and Well Being
Case-Control Studies
Mouthwash use and cancer of the head and neck
head and neck cancer
business
Digestive Diseases
Follow-Up Studies
Subjects
Details
- ISSN :
- 14735709
- Volume :
- 25
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
- Accession number :
- edsair.doi.dedup.....38faba1f9a85117fd154e63847406ed0