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Impact and risk factors of non-adherence to 5-aminosalicylates in quiescent ulcerative colitis evaluated by an electronic management system
- Source :
- INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA, instname
- Publication Year :
- 2019
-
Abstract
- To determine the impact of non-adherence to 5-Aminosalicylates (5-ASA) on the risk of flares and to identify risk factors of non-adherence. Observational, cohort study of ulcerative colitis (UC) patients in clinical remission at least 6 months on 5-ASA monotherapy maintenance prescribed by an electronic management program. Adherence was considered when 80% of the prescribed 5-ASA had been dispensed at the pharmacy. The study analyzed the existence and degree of 5-ASA adherence, disease course, UC phenotypic expression, and 5-ASA dose and regimen, and consumption of non-UC chronic drugs during 2-year follow-up. The study included 274 patients, 49% males with a median age of 38 (27–49) years old. Overall, 41% of patients were non-adherent to 5-ASA. Risk of flares was reduced in the adherent group (36% vs 54%; OR = 0,484; p = 0,004), mainly the mild ones (26% vs 38%; OR = 0,559; p = 0,031). Non-adherence was associated with younger age at diagnosis (32 (26–45) vs 41.5 (21–50), p = 0.000) and no-consumption of other chronic treatments (1.1 vs 2.1; OR = 1709; p = 0,048). Non-adherence to 5-ASA evaluated by the pharmaceutical management system was at 41% with a higher risk of relapse. Younger patients and patients who do not receive non-UC chronic treatments showed lower adherence rate.
- Subjects :
- Adult
Male
medicine.medical_specialty
Younger age
Time Factors
Pharmacy
Medication Adherence
03 medical and health sciences
Electronic Prescribing
0302 clinical medicine
Recurrence
Risk Factors
Internal medicine
Medicine
Humans
Mesalamine
Proportional Hazards Models
business.industry
Gastroenterology
Hepatology
Middle Aged
medicine.disease
Ulcerative colitis
Non adherence
Regimen
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Observational study
Colitis, Ulcerative
Female
business
Cohort study
Subjects
Details
- ISSN :
- 14321262 and 01791958
- Volume :
- 34
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of colorectal disease
- Accession number :
- edsair.doi.dedup.....38fe4d78cf703c61f00ffcfafbd35709