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Feasibility of interstitial diffuse optical tomography using cylindrical diffusing fibers for prostate PDT
- Source :
- Physics in Medicine and Biology. 58:3461-3480
- Publication Year :
- 2013
- Publisher :
- IOP Publishing, 2013.
-
Abstract
- Interstitial diffuse optical tomography (DOT) has been used to characterize spatial distribution of optical properties for prostate photodynamic therapy (PDT) dosimetry. We have developed an interstitial DOT method using cylindrical diffuse fibers (CDFs) as light sources, so that the same light sources can be used for both DOT measurement and PDT treatment. In this novel interstitial CDF-DOT method, absolute light fluence per source strength (in unit of 1 cm(-2)) is used to separate absorption and scattering coefficients. A mathematical phantom and a solid prostate phantom including anomalies with known optical properties were used, respectively, to test the feasibility of reconstructing optical properties using interstitial CDF-DOT. Three dimension spatial distributions of the optical properties were reconstructed for both scenarios. Our studies show that absorption coefficient can be reliably extrapolated while there are some cross talks between absorption and scattering properties. Even with the suboptimal reduced scattering coefficients, the reconstructed light fluence rate agreed with the measured values to within ±10%, thus the proposed CDF-DOT allows greatly improved light dosimetry calculation for interstitial PDT.
- Subjects :
- Male
Optical fiber
Materials science
Physics::Medical Physics
Article
Imaging phantom
law.invention
Optics
law
Humans
Tomography, Optical
Light Dosimetry
Dosimetry
Radiology, Nuclear Medicine and imaging
Absorption (electromagnetic radiation)
Optical Fibers
Radiological and Ultrasound Technology
Phantoms, Imaging
business.industry
Scattering
Prostatic Neoplasms
Reproducibility of Results
Diffuse optical imaging
Photochemotherapy
Attenuation coefficient
Feasibility Studies
business
Subjects
Details
- ISSN :
- 13616560 and 00319155
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Physics in Medicine and Biology
- Accession number :
- edsair.doi.dedup.....38fe699170b59ac00189193cdccb0e58