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Effects of phyllosilicate clay on the metabolic profile of aflatoxin B1 in Fischer-344 rats
- Source :
- Toxicology Letters. 75:145-151
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- The phyllosilicate clay, hydrated sodium calcium aluminosilicate (HSCAS), has been shown to prevent aflatoxicosis in farm animals by reducing the bioavailability of aflatoxin. The present study was designed to determine the effects of HSCAS on the metabolism of aflatoxin B1 (AFB1) in an aflatoxin-sensitive species. Male Fischer-344 rats were orally dosed with 1.0, 0.5, 0.25 and 0.125 mg AFB1/kg body weight alone and in combination with 0.5% HSCAS. Urine samples were collected after 6, 24, 36, and 48 h. Aflatoxin M1 (AFM1) and aflatoxin P1 (AFP1) were detected in most urine samples, with or without HSCAS. AFM1 was found to be the major metabolite. Metabolite concentrations were significantly decreased in the presence of HSCAS, and more importantly, no additional metabolites were detected. Our results suggest that the AFB1-HSCAS complex was not significantly dissociated in vivo, and support earlier findings that HSCAS tightly binds aflatoxin.
- Subjects :
- Male
Aflatoxin
Aflatoxin B1
medicine.medical_treatment
Hydrated Sodium Calcium Aluminosilicate
Metabolite
food and beverages
General Medicine
Urine
Toxicology
Chromatography, Affinity
Rats, Inbred F344
Rats
Bioavailability
chemistry.chemical_compound
Biochemistry
chemistry
Toxicity
medicine
Animals
Aluminum Silicates
Food science
Antidote
Mycotoxin
Chromatography, High Pressure Liquid
Subjects
Details
- ISSN :
- 03784274
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Toxicology Letters
- Accession number :
- edsair.doi.dedup.....3920f65d1e698c11523f3f2a85075129