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Effective uric acid-lowering treatment for hypertensive patients with hyperuricemia
- Source :
- Hypertension Research. 40:259-263
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Uric acid (UA) has been associated with hypertension, renal disease and cardiovascular disease. The aim of the present study was to compare the UA-lowering effects of a standard dose of the UA synthesis inhibitor febuxostat to a standard dose of the uricosuric agent benzbromarone, and to investigate the effects of a low-dose combination of both agents in hypertensive patients with hyperuricemia. Twenty hypertensive patients with inadequate UA control were administered febuxostat 40 mg (Feb), benzbromarone 50 mg (Ben) and febuxostat 20 mg and benzbromarone 25 mg (feb/ben) for 3 months each in a randomized modified crossover manner. UA metabolism, blood pressure (BP) and the indices of organ damage were assessed at baseline and the end of each treatment period. No significant changes were observed in BP or estimated glomerular filtration rate (eGFR) after the treatment with each UA-lowering regimen. The change in UA was significantly greater with feb/ben than with Feb. The excretion of UA and clearance of UA were higher with Ben than with Feb and feb/ben. Urinary 8-hydroxydeoxyguanosine and liver-type fatty-acid-binding protein levels were slightly lower with Ben, whereas flow-mediated dilation was slightly higher with feb/ben and Ben. The UA-lowering effects of the low-dose combination of the UA synthesis inhibitor and uricosuric agent were greater than those of the standard dose of each agent alone. The uricosuric agent may be more effective at improving vascular function than the UA synthesis inhibitor. Thus, the appropriate management of hyperuricemia with uricosuric drugs appears to be useful for hypertensive patients with hyperuricemia.
- Subjects :
- Male
medicine.medical_specialty
Uricosuric
Physiology
Urology
Renal function
Hyperuricemia
030204 cardiovascular system & hematology
Pharmacology
Gout Suppressants
03 medical and health sciences
chemistry.chemical_compound
Benzbromarone
Febuxostat
0302 clinical medicine
Uricosuric Agent
Internal Medicine
medicine
Humans
Aged
030203 arthritis & rheumatology
Cross-Over Studies
business.industry
Middle Aged
medicine.disease
Uric Acid
Treatment Outcome
Blood pressure
chemistry
Hypertension
Uric acid
Drug Therapy, Combination
Female
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 13484214 and 09169636
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Hypertension Research
- Accession number :
- edsair.doi.dedup.....396df75cd8af97608bc9d9d71041fdfc