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A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
- Publication Year :
- 2020
-
Abstract
- An on-chip transducer, for monitoring noninvasively the insulin bio-availability in real time after administration in clinical diabetology, is proposed. The bioavailability is assessed as insulin decrease in situ after administration by means of local impedance measurement. Inter-and-intra individual reproducibility is enhanced by a personalized model, specific for the subject, identified and validated during each insulin administration. Such a real-time noninvasive bioavailability measurement allows to increase the accuracy of insulin bolus administration, by attenuating drawbacks of glycemic swings significantly. In the first part of this paper, the concept, the architecture, and the operation of the transducer, as well as details about its prototype, are illustrated. Then, the metrological characterization and validation are reported in laboratory, in vitro on eggplants, ex vivo on pig abdominal non-perfused muscle, and in vivo on a human subject, using injection as a reference subcutaneous delivery of insulin. Results of significant intra-individual reproducibility in vitro and ex vivo point out noteworthy scenarios for assessing insulin bioavailability in clinical diabetology.
- Subjects :
- 0301 basic medicine
Blood Glucose
medicine.medical_specialty
Swine
Science
medicine.medical_treatment
Injections, Subcutaneous
Biological Availability
Diabetes Therapy
Article
03 medical and health sciences
0302 clinical medicine
Insulin Infusion Systems
In vivo
medicine
Animals
Humans
Hypoglycemic Agents
Insulin
Glycemic
Reproducibility
Multidisciplinary
business.industry
Blood Glucose Self-Monitoring
Diabetology
Bioavailability
030104 developmental biology
Diabetes Mellitus, Type 1
Drug delivery
Medicine
business
Biomedical engineering
030217 neurology & neurosurgery
Ex vivo
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
- Accession number :
- edsair.doi.dedup.....396f53bd23e946020ae8ec15e6dbeccc