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Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle-Brachial Index
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2020
-
Abstract
- Background Upstroke time is the transit time from the nadir to peak of the waveform of pulse volume recording. The purpose of this study was to determine whether upstroke time at the ankle is a useful vascular marker for detecting patients with advanced atherosclerosis in combination with ankle‐brachial index (ABI). Methods and Results We measured upstroke time and ABI in 2313 subjects (mean age, 61.2±15.3 years). The prevalence of coronary artery disease (CAD) was significantly higher in patients with prolonged upstroke time (≥180 ms) than in subjects with normal upstroke time (P P =0.02). In 1954 subjects with normal ABI (1.00 ≤ ABI ≤ 1.40), the prevalence of CAD was significantly higher in patients with prolonged upstroke time than in subjects with normal upstroke time (29.5% versus 10.6%; P P =0.001), whereas there was no significant association between upstroke time and CAD in subjects with low ABI (P =0.44). Conclusions Upstroke time may be a useful vascular marker for detecting patients with CAD, especially in subjects with normal ABI who are usually considered not to have advanced atherosclerosis by ABI measurement alone. More attention should be paid to upstroke time for detecting patients with advanced atherosclerosis. Registration URL: https://www.umin.ac.jp ; Unique identifier: UMIN000039512.
- Subjects :
- Male
medicine.medical_specialty
Transit time
Coronary Artery Disease
Diagnostic Testing
Pulse Wave Analysis
Coronary artery disease
Predictive Value of Tests
Internal medicine
medicine
Odds Ratio
Prevalence
Humans
Coronary Heart Disease
Ankle Brachial Index
cardiovascular diseases
Aged
Original Research
business.industry
Pulse volume
Middle Aged
medicine.disease
Atherosclerosis
medicine.anatomical_structure
Cross-Sectional Studies
Cardiology
Biomarker (medicine)
biomarker
Female
Ankle
Cardiology and Cardiovascular Medicine
business
Nadir (topography)
Subjects
Details
- ISSN :
- 20479980
- Volume :
- 9
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....397d653117dcd92a8ef96c1e27a5a254