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P-glycoprotein (ABCB1) and oxidative stress: Focus on Alzheimer's disease
- Source :
- Oxidative Medicine and Cellular Longevity, Vol 2017 (2017), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2017
-
Abstract
- ATP-binding cassette (ABC) transporters, in particular P-glycoprotein (encoded by ABCB1), are important and selective elements of the blood-brain barrier (BBB), and they actively contribute to brain homeostasis. Changes in ABCB1 expression and/or function at the BBB may not only alter the expression and function of other molecules at the BBB but also affect brain environment. Over the last decade, a number of reports have shown that ABCB1 actively mediates the transport of beta amyloid (Aβ) peptide. This finding has opened up an entirely new line of research in the field of Alzheimer’s disease (AD). Indeed, despite intense research efforts, AD remains an unsolved pathology and effective therapies are still unavailable. Here, we review the crucial role of ABCB1 in the Aβtransport and how oxidative stress may interfere with this process. A detailed understanding of ABCB1 regulation can provide the basis for improved neuroprotection in AD and also enhanced therapeutic drug delivery to the brain.
- Subjects :
- 0301 basic medicine
Aging
Pathology
medicine.medical_specialty
ATP Binding Cassette Transporter, Subfamily B
Amyloid
Receptor for Advanced Glycation End Products
Drug delivery to the brain
ATP-binding cassette transporter
Review Article
Biology
medicine.disease_cause
Blood–brain barrier
Biochemistry
Neuroprotection
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
medicine
ABCB1, Alzherimer's disease, oxidative stress, neuroprotection
Animals
Humans
lcsh:QH573-671
Amyloid beta-Peptides
lcsh:Cytology
Cell Biology
General Medicine
medicine.disease
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
Blood-Brain Barrier
Alzheimer's disease
Carrier Proteins
Neuroscience
030217 neurology & neurosurgery
Homeostasis
Oxidative stress
Low Density Lipoprotein Receptor-Related Protein-1
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity, Vol 2017 (2017), Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....399717fe5a79264538ccf374964fc4a0