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Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar
- Source :
- PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (7), pp.e0004827. ⟨10.1371/journal.pntd.0004827⟩, PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004827 (2016)
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- Background Rift Valley fever (RVF) is a vector-borne disease affecting ruminants and humans. Madagascar was heavily affected by RVF in 2008–2009, with evidence of a large and heterogeneous spread of the disease. The identification of at-risk environments is essential to optimize the available resources by targeting RVF surveillance in Madagascar. Herein, the objectives of our study were: (i) to identify the environmental factors and areas favorable to RVF transmission to both cattle and human and (ii) to identify human behaviors favoring human infections in Malagasy contexts. Methodology/Principal Findings First, we characterized the environments of Malagasy communes using a Multiple Factor Analysis (MFA). Then, we analyzed cattle and human serological data collected at national level using Generalized Linear Mixed Models, with the individual serological status (cattle or human) as the response, and MFA factors, as well as other potential risk factors (cattle density, human behavior) as explanatory variables. Cattle and human seroprevalence rates were positively associated to humid environments (p<br />Author Summary Rift Valley fever virus (RVFV) is a pathogen that causes a vector-borne tropical disease. The disease affects ruminants and humans and severely impacts the health and economy of affected countries. Madagascar was heavily affected by Rift Valley fever (RVF) in 2008–2009, with evidence of a large and heterogeneous spread of the disease. Our study aims at identifying environmental and human-related risk factors for RVFV transmission. First, we characterized Malagasy environments according to their putative influence on RVFV mosquito density and population dynamics. Then we statistically analyzed cattle and human serological data collected at a national level with the individual serological status as response, and Malagasy environments previously characterized by climatic and landscape variables as well as other potential risk factors as explanatory variables. Our results identified humid environments of the western, north-western and eastern parts of the island as risky areas. The identification of at-risk environments is essential to focus veterinary surveillance and control of RVFV.
- Subjects :
- Veterinary medicine
Epidemiology
Pathology and Laboratory Medicine
law.invention
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Analyse du risque
MESH: Cattle Diseases
MESH: Animals
Neglected tropical diseases
Mammals
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
MESH: Middle Aged
000 - Autres thèmes
Fièvre de la Vallée du Rift
Anopheles
Ruminants
3. Good health
Transmission (mechanics)
MESH: Young Adult
Densité de population
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Enzootic
Infectious diseases
L72 - Organismes nuisibles des animaux
Genre humain
Bétail
Livestock
lcsh:RC955-962
MESH: Culex
Microbiology
MESH: Anopheles
03 medical and health sciences
MESH: Cross-Sectional Studies
Madagascar
MESH: Humans
MESH: Seroepidemiologic Studies
Tropical diseases
Public Health, Environmental and Occupational Health
Organisms
lcsh:RA1-1270
MESH: Adult
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
15. Life on land
medicine.disease
Invertebrates
Insect Vectors
030104 developmental biology
Africa
Cattle
MESH: Female
MESH: Antibodies, Viral
0301 basic medicine
RNA viruses
Cattle Diseases
Disease Vectors
L73 - Maladies des animaux
Mosquitoes
Serology
Geographical Locations
MESH: Madagascar
law
Zoonoses
Facteur de risque
Bunyaviruses
Medicine and Health Sciences
MESH: Rift Valley Fever
Comportement humain
Rift Valley fever
2. Zero hunger
biology
lcsh:Public aspects of medicine
Agriculture
Facteur du milieu
Medical microbiology
Insects
MESH: Cattle
Vecteur de maladie
Vertebrates
Viruses
MESH: Rift Valley fever virus
Seasons
Pathogens
Research Article
lcsh:Arctic medicine. Tropical medicine
Zone humide
Arthropoda
Distribution géographique
Culex
030231 tropical medicine
Viral diseases
MESH: Insect Vectors
Virus de la fièvre de la vallée du Rift
Sérologie
Bovines
medicine
Seroprevalence
Animals
MESH: Environment
Transmission des maladies
Biology and life sciences
Viral pathogens
Morbidité
biology.organism_classification
Rift Valley fever virus
MESH: Male
Microbial pathogens
Amniotes
People and Places
Earth Sciences
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Subjects
Details
- Language :
- English
- ISSN :
- 19352727 and 19352735
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (7), pp.e0004827. ⟨10.1371/journal.pntd.0004827⟩, PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004827 (2016)
- Accession number :
- edsair.doi.dedup.....399d0b7b7ddf90f761d550600e15d2ea