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Atovaquone-Proguanil Remains a Potential Stopgap Therapy for Multidrug-Resistant Plasmodium falciparum in Areas along the Thai-Cambodian Border
- Source :
- Antimicrobial Agents and Chemotherapy. 60:1896-1898
- Publication Year :
- 2016
- Publisher :
- American Society for Microbiology, 2016.
-
Abstract
- Our recent report of dihydroartemisinin-piperaquine failure to treat Plasmodium falciparum infections in Cambodia adds new urgency to the search for alternative treatments. Despite dihydroartemisinin-piperaquine failure, and higher piperaquine 50% inhibitory concentrations (IC 50 s) following reanalysis than those previously reported, P. falciparum remained sensitive to atovaquone (ATQ) in vitro . There were no point mutations in the P. falciparum cytochrome b ATQ resistance gene. Mefloquine, artemisinin, chloroquine, and quinine IC 50 s remained comparable to those from other recent reports. Atovaquone-proguanil may be a useful stopgap but remains susceptible to developing resistance when used as blood-stage therapy.
- Subjects :
- 0301 basic medicine
Proguanil
Plasmodium falciparum
030231 tropical medicine
030106 microbiology
Clinical Therapeutics
Biology
Pharmacology
Antimalarials
03 medical and health sciences
0302 clinical medicine
Parasitic Sensitivity Tests
Chloroquine
Piperaquine
parasitic diseases
medicine
Humans
Pharmacology (medical)
Malaria, Falciparum
Artemisinin
Atovaquone
Base Sequence
Mefloquine
Sequence Analysis, DNA
DNA, Protozoan
Thailand
biology.organism_classification
Virology
Atovaquone/proguanil
Artemisinins
Drug Resistance, Multiple
Drug Combinations
Infectious Diseases
Quinolines
Cambodia
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....39dcc1f8df8afd7594bb5a9b936534c5