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Revisiting the Interaction of γδ T-Cells and B-Cells
Revisiting the Interaction of γδ T-Cells and B-Cells
- Source :
- Cells, Cells, Vol 9, Iss 3, p 743 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence of γδ T-cells seems to promote the generation of antibodies against “self” and less against challenging pathogens. More recently, these hypotheses were supported using γδ T-cell-deficient mouse strains, in different mouse models of systemic lupus erythematous, and after induction of epithelial cell damage. Together, these studies suggest that the link between γδ T-cells and the production of autoantibodies may be more relevant for the development of autoimmune diseases than generally acknowledged and thus targeting γδ T-cells could represent a new therapeutic strategy. In this review, we focus on what is known about the communication between γδ T-cells and B-cells, and we discuss the importance of this interaction in the context of autoimmunity.
- Subjects :
- 0301 basic medicine
autoantibodies
T-Lymphocytes
B-cells
Context (language use)
Review
Cell Communication
medicine.disease_cause
Autoimmune Diseases
Autoimmunity
03 medical and health sciences
0302 clinical medicine
Immune system
γδ T-cells
medicine
Animals
Humans
lcsh:QH301-705.5
Interleukin 4
B-Lymphocytes
γδ T–B-cell interaction
biology
Systemic lupus
IL-4
Autoantibody
Germinal center
Receptors, Antigen, T-Cell, gamma-delta
General Medicine
Germinal Center
030104 developmental biology
lcsh:Biology (General)
Immunology
biology.protein
Antibody
030215 immunology
Subjects
Details
- ISSN :
- 20734409
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....39e59246477a0d1c2c0c41c66b9e445d
- Full Text :
- https://doi.org/10.3390/cells9030743