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Selenium-platinum coordination compounds as novel anticancer drugs: selectively killing cancer cells via a reactive oxygen species (ROS)-mediated apoptosis route
- Source :
- Chemistry, an Asian journal. 9(8)
- Publication Year :
- 2014
-
Abstract
- We report the preparation of selenium-containing platinum-based anticancer drug EG-Se/Pt. EG-Se/Pt was obtained from the coordination of selenium-containing molecules (EG-Se) with cisplatin (CDDP). The structure of EG-Se/Pt was characterized by (1) H and (77) Se NMR spectroscopy, XPS, ESI-MS, and MALDI-TOF. In aqueous solution, EG-Se/Pt self-assembles to form spherical aggregates. EG-Se/Pt shows enhanced stability against dilution and high salt concentration compared with EG-Se. EG-Se/Pt induces cell apoptosis via reactive oxygen species (ROS), which leads to high selectivity between cancer cells and normal cells in cytotoxicity assays. More importantly, EG-Se/Pt effectively inhibits tumor growth in vivo in tumor-bearing mice. It is anticipated that tuning the ROS level through the assembly of selenium-containing molecules can be a general method to realize anticancer selectivity.
- Subjects :
- Stereochemistry
chemistry.chemical_element
Antineoplastic Agents
Apoptosis
Biochemistry
Coordination complex
Selenium
In vivo
Cell Line, Tumor
Neoplasms
medicine
Humans
Cytotoxicity
Platinum
Cisplatin
chemistry.chemical_classification
Reactive oxygen species
Spectrum Analysis
Organic Chemistry
General Chemistry
Combinatorial chemistry
chemistry
Cancer cell
Reactive Oxygen Species
medicine.drug
Subjects
Details
- ISSN :
- 1861471X
- Volume :
- 9
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Chemistry, an Asian journal
- Accession number :
- edsair.doi.dedup.....39e86dc2f1684a2cdf2be73910651d70