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Expression of connective tissue growth factor and interleukin-11 in intratumoral tissue is associated with poor survival after curative resection of hepatocellular carcinoma
- Source :
- Molecular biology reports. 39(5)
- Publication Year :
- 2011
-
Abstract
- In the present study, we evaluated the prognostic value of intratumoral and peritumoral expression of connective tissue growth factor (CTGF), transforming growth factor-beta 1 (TGF-β1), and interleukin-11 (IL-11) in patients with hepatocellular carcinoma (HCC) after curative resection. Expression of CTGF, TGF-β1, and IL-11 was assessed by immunohistochemical staining of tissue microarrays containing paired tumor and peritumoral liver tissue from 290 patients who had undergone hepatectomy for histologically proven HCC. The prognostic value of these and other clinicopathologic factors were evaluated. The median follow-up time was 54.3 months (range, 4.3–118.3 months). High intratumoral CTGF expression was associated with vascular invasion (P = 0.015), intratumoral IL-11 expression correlated with higher tumor node metastasis (TNM) stage (P = 0.009), and peritumoral CTGF overexpression correlated with lack of tumor encapsulation (P = 0.031). Correlation analysis of these proteins revealed that intratumoral CTGF and IL-11 correlated with high intratumoral TGF-β1 expression (r = 0.325, P
- Subjects :
- Carcinoma, Hepatocellular
medicine.medical_treatment
Connective tissue
Kaplan-Meier Estimate
Genetics
Carcinoma
medicine
Biomarkers, Tumor
Humans
Molecular Biology
Tissue microarray
integumentary system
business.industry
Liver Neoplasms
Connective Tissue Growth Factor
General Medicine
medicine.disease
Interleukin-11
Prognosis
Immunohistochemistry
CTGF
Interleukin 11
medicine.anatomical_structure
Tissue Array Analysis
Hepatocellular carcinoma
Immunology
Cancer research
Hepatectomy
business
Subjects
Details
- ISSN :
- 15734978
- Volume :
- 39
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Molecular biology reports
- Accession number :
- edsair.doi.dedup.....39fa911449cd6ebc684251bdc68d0fc7