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Comparison of first- and second-generation drug-eluting stent efficacies for treating left main and/or three-vessel disease: a propensity matched study

Authors :
Toshiya Muramatsu
Hideyuki Takimura
Motoharu Araki
Shigemitsu Shirai
Kenji Makino
Takashi Maruyama
Yasunari Sakamoto
Yoshiaki Ito
Hiroya Takafuji
Keisuke Hirano
Takahiro Tokuda
Tsuyoshi Sakai
Yohsuke Honda
Shinsuke Mori
Takuro Takama
Norihiro Kobayashi
Masakazu Tsutsumi
Masahiro Yamawaki
Source :
Heart and Vessels. 31:1930-1942
Publication Year :
2016
Publisher :
Springer Science and Business Media LLC, 2016.

Abstract

The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexity of coronary artery disease using synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) scores. Between April 2007 and December 2012, 341 patients with LM and/or 3VD were treated by percutaneous coronary intervention; 154 with first-generation DES and 137 with second-generation DES. After propensity matching, 101 patients remained in each group. The rate of target lesion revascularization (TLR) and major adverse cardiac event (MACE) were compared. TLR and MACE at 2 years were more common in the first- compared with second-generation DES group (TLR 19.8 vs. 8.9 %; p = 0.016, MACE 24.8 vs. 10.9 %; p = 0.008). In patients with low (0-22) and intermediate (23-32) SYNTAX scores, TLR and MACE tended to occur more often with first-generation DES group. In patients with high SYNTAX scores (≧33), TLR and MACE were significantly more common with first-generation DES group (TLR 29.0 vs. 11.1 %; p = 0.035, MACE 35.5 vs. 13.9 %; p = 0.034). Compared with first-generation DES, second-generation DES proved beneficial in reducing risk of TLR and MACE in patients with LM and/or 3VD, particularly among those with high SYNTAX scores (≧33).

Details

ISSN :
16152573 and 09108327
Volume :
31
Database :
OpenAIRE
Journal :
Heart and Vessels
Accession number :
edsair.doi.dedup.....3a064cfc230455fa3d3e6989e145c9ae