Back to Search
Start Over
An Artemisinin Derivative of Praziquantel as an Orally Active Antischistosomal Agent
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 11, p e112163 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science, 2014.
-
Abstract
- Background Schistosomiasis is a major health problem in tropical and sub-tropical areas caused by species of trematode belonging to the genus Schistosoma. The treatment and control of this disease has been relying on the use of a single drug praziquantel. However, the drug resistance concern urged the development of new drugs against schistosoma. Here, we report our systematic biological evaluation of DW-3-15, a new lead compound developed based on our conjugation design rationale as an effective anti-schistosomal agent. Methodology/Principal Findings The antischistosomal activity of DW-3-15 was systematically evaluated in S. japonicum infected mouse model for its stage-sensitivity and dose response. The results revealed that DW-3-15 exhibited 60–85% worm reduction rate against different development stage of worm. Scanning electron microscopy (SEM) observation indicated that DW-3-15 may damage to the tegument of male schistosomes. Conclusions/Significance Our results demonstrated that DW-3-15 showed potent anti-schistosomal activities in vivo. The results strongly support our conjugation design strategy of artemisinin analogs and further development of DW-3-15 as a new lead compound as anti-schistosomal agent.
- Subjects :
- lcsh:Medicine
Administration, Oral
Schistosomiasis
Drug resistance
Pharmacology
Praziquantel
chemistry.chemical_compound
Mice
Schistosomicides
parasitic diseases
Medicine and Health Sciences
Parasitic Diseases
Medicine
Animals
Artemisinin
lcsh:Science
Schistosoma
Mice, Inbred ICR
Multidisciplinary
biology
business.industry
Schistosoma japonicum
lcsh:R
Biology and Life Sciences
biology.organism_classification
medicine.disease
Artemisinins
Disease Models, Animal
chemistry
Artesunate
Schistosomiasis japonica
lcsh:Q
Parasitology
Female
Schistosoma mansoni
business
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....3a0dcb1bae979198d0885a490ee68916