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Enzymology of human myometrium: Variations related to the hormonal milieu
- Source :
- Archives of Gynecology. 240:233-240
- Publication Year :
- 1987
- Publisher :
- Springer Science and Business Media LLC, 1987.
-
Abstract
- The activities of various enzymes involved in glycolysis, tricarboxylic acid cycle and fatty acid oxidation were assayed in human myometrium. A gradient of the activities from fundal to cervical myometrium was observed. In contrast to studies performed in rodents, cyclic changes of glycolytic enzymes could not be detected. Hydroxyacyl-CoA-dehydrogenase (HAD) activity was higher in secretory phase myometrium and in cases with cystic hyperplasia of the endometrium than in proliferative phase myometrium. In pregnant myometrium, lactate dehydrogenase (LDH) and glycogen phosphorylase (GLP) were increased and in postmenopausal myometrium the activities of phosphofructokinase (PFK), LDH and succinate dehydrogenase (SDH) were decreased as compared to proliferative phase myometrium. We conclude that in the human myometrium, except for HAD, activities of enzymes involved in fuel metabolism are stable throughout the menstrual cycle and that only prolonged hormonal stimulation leads to alterations of some enzyme activities.
- Subjects :
- Adult
medicine.medical_specialty
Phosphorylases
Phosphofructokinase-1
Biology
Endometrium
Glycogen phosphorylase
chemistry.chemical_compound
Pregnancy
Hexokinase
Lactate dehydrogenase
Internal medicine
Follicular phase
medicine
Humans
Phosphofructokinase 1
Menstrual Cycle
reproductive and urinary physiology
Abdominal Muscles
Aged
L-Lactate Dehydrogenase
urogenital system
Myometrium
3-Hydroxyacyl CoA Dehydrogenases
Proteins
Obstetrics and Gynecology
General Medicine
Middle Aged
musculoskeletal system
female genital diseases and pregnancy complications
Succinate Dehydrogenase
Citric acid cycle
medicine.anatomical_structure
Endocrinology
chemistry
Endometrial Hyperplasia
Female
Menopause
Energy Metabolism
hormones, hormone substitutes, and hormone antagonists
Phosphofructokinase
Subjects
Details
- ISSN :
- 14320711 and 01709925
- Volume :
- 240
- Database :
- OpenAIRE
- Journal :
- Archives of Gynecology
- Accession number :
- edsair.doi.dedup.....3a157bdf22dfe906303d65459dace8d8