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First-line haploidentical stem cell transplantation in children and adolescents with severe aplastic anemia using mobilized peripheral blood as source of CD34+: Single-institutional experience in a transplant center from northeast Mexico
- Source :
- Pediatric transplantationREFERENCES. 25(7)
- Publication Year :
- 2021
-
Abstract
- Introduction The only curative treatment for severe aplastic anemia in children is an allogeneic stem cell transplant; however, few patients have a matched related or unrelated donor. Haploidentical stem cell transplantation (haplo-SCT) using bone marrow (BM) and peripheral blood stem cells (PBSC) has been recently described as effective and safe. In this study, we retrospectively report the outcome of twelve pediatric patients who underwent haplo-SCT using only PBSC. Methods The conditioning regimen consisted on rabbit anti-thymocyte globulin (r-ATG) 2.5 mg/kg/d on days -7, -6,-5, and -4, and cyclophosphamide (Cy) 50 mg/kg/d on days -3 and -2. We used Cy 50 mg/kg/d on days +3 and +4, tacrolimus and mycophenolic acid as graft versus host disease (GVHD) prophylaxis. Results The median follow-up was 1,099 days (45-1258 days). The overall survival rate up-to-date is 83.3%. In 10 of the 12 patients, a sustained graft was achieved. None of the patients had acute or chronic GVHD. Conclusions Haplo-SCT could be established as a first-line treatment when there is no matched related or unrelated donor. According to this short sample and previous reports, PBSC are a feasible option effectively used as the sole source of stem cells. Additionally, post-transplant cyclophosphamide remains a good strategy for GVHD prevention.
- Subjects :
- Male
medicine.medical_specialty
Transplantation Conditioning
Cyclophosphamide
Adolescent
Antigens, CD34
Gastroenterology
Mycophenolic acid
Internal medicine
medicine
Humans
Aplastic anemia
Child
Mexico
Retrospective Studies
Transplantation
business.industry
Hematopoietic Stem Cell Transplantation
Anemia, Aplastic
Infant
medicine.disease
Tacrolimus
surgical procedures, operative
medicine.anatomical_structure
Graft-versus-host disease
Child, Preschool
Pediatrics, Perinatology and Child Health
Transplantation, Haploidentical
Female
Bone marrow
Stem cell
business
medicine.drug
Subjects
Details
- ISSN :
- 13993046
- Volume :
- 25
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Pediatric transplantationREFERENCES
- Accession number :
- edsair.doi.dedup.....3a27319bb7962be85fb4e8fbff4fffb8