Back to Search Start Over

Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma

Authors :
Esther E. E. Drees
Julia Driessen
Gerben J. C. Zwezerijnen
Sandra A. W. M. Verkuijlen
Jakoba J. Eertink
Monique A. J. van Eijndhoven
Nils J. Groenewegen
Andrea Vallés‐Martí
Daphne de Jong
Ronald Boellaard
Henrica C. W. de Vet
Dirk M. Pegtel
Josée M. Zijlstra
Pathology
Radiology and nuclear medicine
CCA - Imaging and biomarkers
Hematology laboratory
Medical oncology laboratory
Amsterdam Neuroscience - Brain Imaging
Epidemiology and Data Science
APH - Methodology
Hematology
Source :
EJHaem, 3(3), 908-912, Drees, E E E, Driessen, J, Zwezerijnen, G J C, Verkuijlen, S A W M, Eertink, J J, van Eijndhoven, M A J, Groenewegen, N J, Vallés-Martí, A, de Jong, D, Boellaard, R, de Vet, H C W, Pegtel, D M & Zijlstra, J M 2022, ' Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma ', EJHaem, vol. 3, no. 3, pp. 908-912 . https://doi.org/10.1002/jha2.432
Publication Year :
2022

Abstract

Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.

Subjects

Subjects :
General Medicine

Details

Language :
English
ISSN :
26886146
Database :
OpenAIRE
Journal :
EJHaem, 3(3), 908-912, Drees, E E E, Driessen, J, Zwezerijnen, G J C, Verkuijlen, S A W M, Eertink, J J, van Eijndhoven, M A J, Groenewegen, N J, Vallés-Martí, A, de Jong, D, Boellaard, R, de Vet, H C W, Pegtel, D M & Zijlstra, J M 2022, ' Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma ', EJHaem, vol. 3, no. 3, pp. 908-912 . https://doi.org/10.1002/jha2.432
Accession number :
edsair.doi.dedup.....3a3e91f4fe9547e53dfc6768b4e3d6b8

Tools

Authors Abstract Subjects Details