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Long-Term Kinetics of SARS-CoV-2 Antibodies and Impact of Inactivated Vaccine on SARS-CoV-2 Antibodies Based on a COVID-19 Patients Cohort
- Source :
- Frontiers in Immunology, Vol 13 (2022)
- Publication Year :
- 2021
-
Abstract
- BackgroundUnderstanding the long-term kinetic characteristics of SARS-CoV-2 antibodies and the impact of inactivated vaccines on SARS-CoV-2 antibodies in convalescent patients can provide information for developing and improving vaccination strategies in such populations.MethodsIn this cohort, 402 convalescent patients who tested positive for SARS-CoV-2 by RT-PCR from 1 January to 22 June 2020 in Jiangsu, China, were enrolled. The epidemiological data included demographics, symptom onset, and vaccination history. Blood samples were collected and tested for antibody levels of specific IgG, IgM, RBD-IgG, S-IgG, and neutralizing antibodies using a the commercial magnetic chemiluminescence enzyme immunoassay.ResultsThe median follow-up time after symptom onset was 15.6 months (IQR, 14.6 to 15.8). Of the 402 convalescent patients, 44 (13.84%) received an inactivated vaccine against COVID-19. A total of 255 (80.19%) patients were IgG-positive and 65 (20.44%) were IgM-positive. The neutralizing antibody was 83.02%. Compared with non-vaccinated individuals, the IgG antibody levels in vaccinated people were higher (P=0.007). Similarly, antibody levels for RBD-IgG, S-IgG, and neutralizing antibodies were all highly increased in vaccinated individuals (P0.05). Similar conclusions were drawn for RBD-IgG and the neutralizing antibody.Conclusion15.6 months after symptom onset, the majority of participants remained positive for serum-specific IgG, RBD-IgG, S-IgG, and neutralizing antibodies. For convalescent patients, a single dose of inactivated vaccine against COVID-19 can further boost antibody titres.
- Subjects :
- Adult
Male
China
COVID-19 Vaccines
Adolescent
Immunology
Antibodies, Viral
Cohort Studies
Young Adult
Immunology and Allergy
Humans
antibody responses
Child
Aged
Aged, 80 and over
long-term kinetics
SARS-CoV-2
COVID-19
RC581-607
Middle Aged
vaccination
natural infection
Antibodies, Neutralizing
Immunoglobulin M
Vaccines, Inactivated
Immunoglobulin G
Female
Immunologic diseases. Allergy
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Frontiers in immunology
- Accession number :
- edsair.doi.dedup.....3a3fc1289546dd92fc2d2d8e48fe57d3