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Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality
- Source :
- Circ Res
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Rationale: Although there has been a long-standing interest in the human health effects of vitamin E, a comprehensive analysis of the association between circulating vitamin E and long-term mortality has not been conducted. Objective: Determine whether serum α-tocopherol (the predominant form of vitamin E) is related to long-term overall and cause-specific mortality and elucidate the dose-response relationships with better quantification of the associations. Methods and Results: We conducted a biochemical analysis of 29 092 participants in the ATBC Study (Alpha-Tocopherol, Beta-Carotene Cancer Prevention) that originally tested vitamin E and β-carotene supplementation. Serum α-tocopherol was measured at baseline using high-performance liquid chromatography, and during a 30-year follow-up we identified 23 787 deaths, including deaths from cardiovascular disease (9867), cancer (7687), respiratory disease (2161), diabetes mellitus (119), injuries and accidents (1255), and other causes (2698). After adjusting for major risk factors, we found that men with higher serum α-tocopherol had significantly lower all-cause mortality (hazard ratios=0.83, 0.79, 0.75, and 0.78 for quintile 2 (Q2)–Q5 versus Q1, respectively; P trend P interaction ≤0.006). Conclusions: In this long-term prospective cohort study, higher baseline serum α-tocopherol biochemical status was associated with lower risk of overall mortality and mortality from all major causes. Our data support the long-term health benefits of higher serum α-tocopherol for overall and chronic disease mortality and should be replicated in other more diverse populations.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Multivariate analysis
Physiology
medicine.medical_treatment
alpha-Tocopherol
030204 cardiovascular system & hematology
Article
Cohort Studies
03 medical and health sciences
Human health
chemistry.chemical_compound
0302 clinical medicine
Neoplasms
Cause of Death
Epidemiology
medicine
Humans
Vitamin E
Prospective Studies
Aged
business.industry
Cause specific mortality
Middle Aged
030104 developmental biology
chemistry
Cardiovascular Diseases
Dietary Supplements
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Follow-Up Studies
Serum vitamin e
Subjects
Details
- ISSN :
- 15244571 and 00097330
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Circulation Research
- Accession number :
- edsair.doi.dedup.....3a4e68b39a7fcaa4fe8e42b6b0648fe1