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Anti-inflammatory and Antioxidant Activity of Nanoencapsulated Curcuminoids Extracted from Curcuma longa L. in a Model of Cutaneous Inflammation
- Source :
- Inflammation. 44:604-616
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before CO application or topical treatment immediately after CO application (200 μg diluted in 70% acetone) with a single dose of Cur and Nano-cur. After 6 h, the animals were anesthetized and euthanized. The ears were sectioned into disks (6.0 mm diameter) and used to determine edema, myeloperoxidase (MPO) activity, and oxidative stress. Photoacoustic spectroscopy (PAS) was used to evaluate the percutaneous penetration of Cur and Nano-cur. Topical treatment with both preparations had a similar inhibitory effect on the development of edema, MPO activity, and the oxidative response. The PAS technique showed that the percutaneous permeation of both topically applied preparations was similar. Oral Nano-cur administration exerted a higher anti-inflammatory effect than Cur. Topical Cur and Nano-cur application at the same dose similarly inhibited the inflammatory and oxidative responses. Oral Nano-cur administration inhibited such responses at doses that were eight times lower than Cur, suggesting the better bioavailability of Nano-cur compared with Cur.Graphical abstract.
- Subjects :
- Male
0301 basic medicine
Antioxidant
Croton Oil
medicine.drug_class
Administration, Topical
medicine.medical_treatment
Immunology
Anti-Inflammatory Agents
Administration, Oral
Pharmacology
Dermatitis, Contact
medicine.disease_cause
Antioxidants
Drug Administration Schedule
Anti-inflammatory
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Nanocapsules
Diarylheptanoids
Edema
medicine
Animals
Immunology and Allergy
Curcuminoid
Curcuma
Peroxidase
Skin
Dose-Response Relationship, Drug
biology
Plant Extracts
technology, industry, and agriculture
biology.organism_classification
Bioavailability
Oxidative Stress
Treatment Outcome
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Myeloperoxidase
biology.protein
medicine.symptom
Biomarkers
Oxidative stress
Phytotherapy
Subjects
Details
- ISSN :
- 15732576 and 03603997
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Inflammation
- Accession number :
- edsair.doi.dedup.....3a6a84463286e1bbbba1e43903f91d47